期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 2022, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.202100840
关键词
Buchwald-Hartwig amination; N-heterocyclic carbene ligands; Palladium indenyl complexes; Suzuki-Miyaura cross-coupling; Weak base route
资金
- Moonshot D2M project
- BOF
- CSC
- Research Foundation - Flanders (FWO) [G099319N]
The synthesis of a series of stable Pd(II)-NHC pre-catalysts with excellent catalytic activity in Suzuki-Miyaura and Buchwald-Hartwig reactions has been successfully achieved in this study, especially when IPrCl is employed as an ancillary ligand. The [Pd(IPr*)Cl(1-Bu-t-indenyl)] complex also exhibited optimal catalytic activity in the challenging Suzuki-Miyaura reaction between esters and arylboronic acids under very mild reaction conditions.
The development of robust, more efficient, general, easily accessible Pd(II)-NHC pre-catalysts remains a key issue in cross-coupling applications. A selection of well-defined, air and moisture stable [Pd(NHC)Cl(1-Bu-t-indenyl)] (NHC=IPr, IPrCl, IMes, SIMes, IPr*) pre-catalysts have been synthesized in good to excellent yields by reacting [Pd(1-Bu-t-indenyl)(mu-Cl)](2) and various NHC.HCl precursors in the presence of the weak base K2CO3 in green acetone. The synthesized Pd(II)-NHC derivatives displayed excellent catalytic activity in classical Suzuki-Miyaura and Buchwald-Hartwig reactions, especially when IPrCl is employed as ancillary ligand. Additionally, in the challenging Suzuki-Miyaura reaction between esters and arylboronic acids, the [Pd(IPr*)Cl(1-Bu-t-indenyl)] complex exhibited the optimum catalytic activity under very mild reaction conditions.
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