4.1 Article

Seasonal expressions of GPR41 and GPR43 in the colon of the wild ground squirrels (Spermophilus dauricus)

期刊

EUROPEAN JOURNAL OF HISTOCHEMISTRY
卷 66, 期 1, 页码 -

出版社

PAGEPRESS PUBL
DOI: 10.4081/ejh.2022.3351

关键词

GPR41; GPR43; colon; wild ground squirrel; seasonal breeding

资金

  1. National Natural Science Foundation of China [21806010]
  2. Fundamental Research Funds for the Central Universities [2018ZY21]
  3. National Training Program of Innovation and Entrepreneurship for Undergraduates [G202110022020, S202010022079, G202010022072]

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GPR41 and GPR43 are important receptors for short-chain fatty acids. They may play a regulatory role in seasonal breeding.
G-protein-coupled receptor 41 (GPR41) and G-protein-coupled receptor 43 (GPR43) are important short-chain fatty acids (SCFAs) receptors. Previous studies indicated that GPR41 and GPR43 are involved in the secretion of gastrointestinal peptides, and glucose and lipid metabolism, and are closely related to obesity and type II dia-betes, and other diseases. The purpose of the study was to explore the relationship of the GPR41 and GPR43 with seasonal breeding, and provide new prospects for further exploring the nutritional needs of breeding. We identified the localization and expression levels of GPR41 and GPR43 in the colon of the wild ground squirrels (Spermophilus dauricus) both in the breeding season and non-breeding season. The histological results revealed that the lumen diameter of the colon had obvious seasonal changes, and the diameter of the colonic lumen in the non-breeding season was larger than that in the breeding season. Immunohistochemical staining suggested that GPR41 and GPR43 are expressed in the simple layer columnar epithelium. In addition, compared with the breeding season, the mRNA and protein expression levels of GPR41 and GPR43 in the colon were higher dur -ing the non-breeding season. In general, these results indicated that GPR41 and GPR43 might play a certain role in regulating seasonal breeding.

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