期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 37, 期 5, 页码 503-512出版社
SPRINGER
DOI: 10.1007/s10654-022-00843-y
关键词
Allergies; Epilepsy; Brain tumours; Multicenter case-control study
资金
- International Agency for Research on Cancer (IARC/WHO)
- European Fifth Framework Program, 'Quality of Life and Management of Living Resources' [QLK4-CT-1999901563]
- International Union against Cancer (UICC)
- Mobile Manufacturers' Forum
- GSM Association
- Australian National Health and Medical Research Council (EME Grant) [219,129]
- Canadian Institutes of Health Research [15 MOP-42525]
- Canada Research Chair programme
- GuzzoCRS Chair in Environment and Cancer
- Fonds de la recherche en sante du Quebec
- Canadian Institutes of Health Research (CIHR)
- Canadian Wireless Telecommunications Association
- l'Association pour la Recherche sur le Cancer (ARC) [5142]
- Orange
- SFR
- Bouygues Telecom
- Emil Aaltonen Foundation
- Academy of Finland
- Deutsches Mobilfunkforschungsprogramm [German Mobile Phone Research Program]'' of the German Federal Ministry of Environment, Nuclear Safety, and Nature Protection
- Ministry of Environment and Traffic of the state of Baden-Wurttemberg
- Ministry of Environment of the state of North Rhine-Westphalia
- MAIFOR Programme of the University of Mainz
- Ministry of Internal Affairs and Communications of Japan
- Health Research Council of New Zealand
- Cancer Society of New Zealand
- Wellington Medical Research Foundation
- Hawke's Bay Medical Research Foundation
- Waikato Medical Research Foundation
- Swedish Research Council
- Swedish Cancer Society
- Health and Safety Executive
- Department of Health
- Mobile Telecommunications, Health and Research (MTHR) program
- Scottish Executive
- O2
- T-Mobile
- Vodafone, '3'
- Mobile Telecommunications, Health and Research (MTHR) programme
This case-control study found a negative association between allergic diseases and the risk of glioma, but no association with meningioma or acoustic neuroma. The previous diagnosis of epilepsy was associated with an increased risk of glioma and meningioma.
We investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case-control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for education and time at interview. Reduced ORs were observed for glioma in relation to physician-diagnosed asthma (OR = 0.73; CI 0.58-0.92), hay fever (OR 0.72; CI 0.61-0.86), and eczema (OR 0.78, CI 0.64-0.94), but not for meningioma or acoustic neuroma. Previous diagnosis of epilepsy was associated with an increased OR for glioma (2.94; CI 1.87-4.63) and for meningioma (2.12; CI 1.27-3.56), but not for acoustic neuroma. This large-scale case-control study adds to the growing evidence that people with allergies have a lower risk of developing glioma, but not meningioma or acoustic neuroma. It also supports clinical observations of epilepsy prior to the diagnosis of glioma and meningioma.
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