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Therapeutic vaccines for breast cancer: Has the time finally come?

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Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

N. Harbeck et al.

Summary: Adjuvant abemaciclib combined with endocrine therapy significantly improved invasive disease-free survival in patients with early breast cancer, with an acceptable safety profile. Ki-67 index was prognostic but did not affect the benefits of abemaciclib. The robust treatment benefit of abemaciclib extended beyond the planned 2-year treatment period.

ANNALS OF ONCOLOGY (2021)

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Commentary: SARS-CoV-2 vaccines and cancer patients

C. Corti et al.

ANNALS OF ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Third-line treatment of HER2-positive advanced breast cancer: From no standard to a Pandora's box

Paolo Tarantino et al.

Summary: HER2+ advanced breast cancer accounts for 15-20% of cases, with standard first- and second-line treatments being dual blockade plus chemotherapy and TDM1. No standard treatment after TDM1 is recommended, but FDA-approved novel anti-HER2 compounds are providing more options. Clinical decision-making needs to consider factors such as trial designs, drug efficacy, toxicity profiles, patient characteristics, and preferences.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Immunology

Subgroup analysis of nelipepimut-S plus GM-CSF combined with trastuzumab versus trastuzumab alone to prevent recurrences in patients with high-risk, HER2 low-expressing breast cancer

R. Connor Chick et al.

Summary: HER2-targeted therapy does not benefit patients with low levels of HER2 expression, but combination therapy may be effective. Subset analysis in TNBC patients showed potential benefits of the HER2-derived vaccine NPS, especially in patients expressing HER2 1+ or HLA-A24. Confirmation of these findings in a phase III trial is warranted.

CLINICAL IMMUNOLOGY (2021)

Review Oncology

Efficacy of cancer vaccines in selected gynaecological breast and ovarian cancers: A 20-year systematic review and meta-analysis

U. Dafni et al.

Summary: A systematic review and meta-analysis evaluated the efficacy of vaccines on breast cancer and ovarian cancer patients. Despite modest results in terms of ORR, therapeutic vaccines in the last 20 years displayed relatively long survival rates and low toxicity, indicating the need for better understanding of underlying mechanisms to further improve vaccine efficacy.

EUROPEAN JOURNAL OF CANCER (2021)

Article Pharmacology & Pharmacy

AE37: a HER2-targeted vaccine for the prevention of breast cancer recurrence

Patrick M. McCarthy et al.

Summary: HER2 is a prevalent growth factor in malignancies, with over-expression linked to poor survival. The novel AE37 vaccine, based on HER2, shows potential in breast and prostate cancer clinical trials. Future trials may expand the use of AE37 in treating other HER2-expressing malignancies.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

Article Oncology

SARS-CoV-2 vaccines for cancer patients: a call to action

Chiara Corti et al.

Summary: The COVID-19 pandemic has affected over 96 million people globally, with cancer patients at a higher risk of severe illness. Efforts to develop effective vaccines are crucial, but cancer patients may be underrepresented in clinical trials. Real-time data on vaccine recipients, including cancer patients, is needed to ensure safety and efficacy. Prioritizing vaccinations for cancer patients and implementing pharmacovigilance registries are important steps in attenuating the consequences of the pandemic for this vulnerable population.

EUROPEAN JOURNAL OF CANCER (2021)

Review Biochemistry & Molecular Biology

Syndecan-1 (CD138), Carcinomas and EMT

John R. Couchman

Summary: Cell surface proteoglycans, such as syndecans, play crucial roles in regulating cell behavior, including interactions with extracellular matrix components and mediating proliferation, adhesion, and migration. In tumors, changes in the levels and distribution of syndecan-1 can have implications for prognosis, with loss of membrane staining and abnormal cytoplasmic or nuclear staining often indicating poor outcomes. Targeting syndecan-1 with antibody-toxin conjugates may hold promise for clinical applications in both myeloma and some carcinomas.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Immunology

The Immunology of Hormone Receptor Positive Breast Cancer

Jonathan Goldberg et al.

Summary: ICB has revolutionized cancer treatment, but has limited efficacy in HR+ breast cancer due to a TME devoid of TILs. TNBC shows clinical responses to ICB due to TIL infiltration, while HR+ breast tumors establish an immune suppressive TME.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Therapeutic cancer vaccines revamping: technology advancements and pitfalls

G. Antonarelli et al.

Summary: The development of cancer vaccines has made significant progress, inducing tumor-specific immune responses and showing remarkable clinical responses in some clinical trials. Technological advances in vaccine development and improvements in vaccine delivery platforms have provided strong support for the development of cancer vaccines, and the applications have extended to other vaccine fields.

ANNALS OF ONCOLOGY (2021)

Review Oncology

Managing side effects of immune checkpoint inhibitors in breast cancer

Carmen Criscitiello et al.

Summary: ICIs have become a significant development in cancer therapy, with recent trials in breast cancer showing promising results. However, the safety of ICIs is affected by irAEs, requiring a focus on managing these adverse events.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Review Oncology

Antibody-Drug Conjugates for the Treatment of Breast Cancer

Chiara Corti et al.

Summary: Metastatic breast cancer is an incurable disease, with chemotherapy often used alongside endocrine therapy and targeted agents. Antibody-drug conjugates (ADCs) offer a promising approach by combining the selectivity of monoclonal antibodies with the cytotoxic properties of chemotherapy, potentially improving the therapeutic index of anticancer drugs. Some ADCs have shown activity in both HER2-positive and HER2-low breast cancer patients, indicating a bystander effect that may help overcome tumor heterogeneity.

CANCERS (2021)

Article Oncology

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Peter M. K. Westcott et al.

Summary: The study reveals that despite low TMB, tumors from patients with microsatellite stable colorectal cancer still express predicted neoantigens, although at lower levels compared to those in colorectal cancer with microsatellite instability. Low expression of neoantigens may lead to immediate T-cell dysfunction, but it can be controlled by restoring priming in tumors with low neoantigen expression.

NATURE CANCER (2021)

Article Oncology

Serial single-cell genomics reveals convergent subclonal evolution of resistance as patients with early-stage breast cancer progress on endocrine plus CDK4/6 therapy

Jason I. Griffiths et al.

Summary: The study reveals that early-stage estrogen receptor-positive breast cancer patients receiving combination cyclin-dependent kinase inhibitors and endocrine therapy develop resistance through a shift from estrogen to alternative growth signal-mediated proliferation, with convergent clonal evolution mechanisms identified.

NATURE CANCER (2021)

Review Oncology

Breast cancer vaccines: Heeding the lessons of the past to guide a path forward

Cinzia Solinas et al.

CANCER TREATMENT REVIEWS (2020)

Review Immunology

HER2-Positive Breast Cancer Immunotherapy: A Focus on Vaccine Development

Atefeh Arab et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2020)

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Expression of tumor-associated antigens in breast cancer subtypes

Giuseppe Curigliano et al.

BREAST (2020)

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Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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DC-CIK as a widely applicable cancer immunotherapy

Shuo Wang et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Article Oncology

ESR1 mutations provide novel targets for breast cancer immunotherapy.

Jonathan Goldberg et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Oncology

Tumor-infiltrating lymphocytes (TILs) in ER+/HER2-breast cancer

C. Criscitiello et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Review Medicine, Research & Experimental

Bacterial and viral vectors as vaccine delivery vehicles for breast cancer therapy

Balamurugan Shanmugaraj et al.

LIFE SCIENCES (2020)

Review Biochemistry & Molecular Biology

The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism

Ye Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Multidisciplinary Sciences

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer

Po-Kai Chuang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Sex-Based Heterogeneity in Response to Lung Cancer Immunotherapy: A Systematic Review and Meta-Analysis

Fabio Conforti et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

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Prevalence and role of HER2 mutations in cancer

Emiliano Cocco et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Review Oncology

Current Landscape of Immunotherapy in Breast Cancer: A Review

Sylvia Adams et al.

JAMA ONCOLOGY (2019)

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Targeting the microenvironment in solid tumors

Carmen Belli et al.

CANCER TREATMENT REVIEWS (2018)

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Developing anti-HER2 vaccines: Breast cancer experience

Aydah Al-Awadhi et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Meeting Abstract Oncology

A phase 1 study of p53MVA vaccine in combination with pembrolizumab.

Vincent M. Chung et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Meeting Abstract Oncology

Breast cancer stem cell autoantibodies to identify women with advanced breast cancer.

Sasha E. Stanton et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Review Oncology

Targeting mutant p53 for efficient cancer therapy

Vladimir J. N. Bykov et al.

NATURE REVIEWS CANCER (2018)

Article Surgery

Immunotherapy for Breast Cancer: Current and Future Strategies

Austin D. Williams et al.

CURRENT SURGERY REPORTS (2017)

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Oncology

The development and use of the E75 (HER2 369-377) peptide vaccine

Guy T. Clifton et al.

FUTURE ONCOLOGY (2016)

Review Oncology

Strategies to modulate the immune system in breast cancer: checkpoint inhibitors and beyond

Cristina Migali et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2016)

Review Biochemistry & Molecular Biology

Natural and therapy-induced immunosurveillance in breast cancer

Guido Kroemer et al.

NATURE MEDICINE (2015)

Article Pathology

Classical pathology and mutational load of breast cancer - integration of two worlds

Jan Budczies et al.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH (2015)

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The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a meta-analysis

Ezzeldin M. Ibrahim et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

Article Immunology

Current status of autologous breast tumor cell-based vaccines

Samantha L. Kurtz et al.

EXPERT REVIEW OF VACCINES (2014)

Review Biotechnology & Applied Microbiology

DNA vaccine for cancer immunotherapy

Benjamin Yang et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Review Immunology

Pathways of Antigen Processing

Janice S. Blum et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

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MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

Patrizia Leone et al.

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Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors

Claudia Marcela Diaz-Montero et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

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Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael S. Lawrence et al.

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Tailoring DNA vaccines: designing strategies against HER2-positive cancers

Cristina Marchini et al.

FRONTIERS IN ONCOLOGY (2013)

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The future of human DNA vaccines

Lei Li et al.

JOURNAL OF BIOTECHNOLOGY (2012)

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Karolina Palucka et al.

NATURE REVIEWS CANCER (2012)

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Viral Vector-Based Therapeutic Cancer Vaccines

Cecilia Larocca et al.

CANCER JOURNAL (2011)

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HER2 genetic heterogeneity in breast carcinoma

Christian Oehlschlegel et al.

JOURNAL OF CLINICAL PATHOLOGY (2011)

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Breast cancer vaccines: a clinical reality or fairy tale?

G Curigliano et al.

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A Tat fusion protein-based tumor vaccine for breast cancer

CT Viehl et al.

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