4.5 Article

Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance

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出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00406-021-01369-2

关键词

Schizophrenia; Cingulate gyrus; Magnetic resonance imaging; Neuropsychological assessment

资金

  1. Projekt DEAL
  2. Bundesministerium fur Bildung und Forschung [01GV0618]

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In this study, the cortical thickness of different subregions of the cingulate gyrus was assessed in patients with schizophrenia-spectrum disorder. The findings suggest that the cortical thickness in the posterior part of the cingulate gyrus is increased and related to illness duration, while cortical thickness in the anterior parts is decreased and unrelated to illness duration. Memory performance is only related to cortical thickness in the anterior parts of the cingulate gyrus.
Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia.

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