期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 87, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2021.103738
关键词
Levothyroxine; Propylthiouracil; Xenopus laevis; Endocrine disruptor chemicals; Biomarkers
The effects of drugs containing synthetic thyroid hormone and an anti-thyroid drug on different early developmental stages of Xenopus laevis vary, with more effective growth retardation in embryos than tadpoles. Inhibition of biomarker enzymes was significant in tadpoles, showing differences in sensitivity and responses to drugs at different stages.
The effects of two drugs containing the synthetic thyroid hormone levothyroxine (LEV) and an anti-thyroid drug containing propylthiouracil (PTU) on the three early life stages of Xenopus laevis were evaluated with the Frog Embryo Teratogenesis Assay-Xenopus, Tadpole Toxicity Test, and Amphibian Metamorphosis Assay using biochemical and morphological markers. Tested drugs caused more effective growth retardation in stage 8 embryos than stage 46 tadpoles. Significant inhibition of biomarker enzymes has been identified in stage 46 tadpoles for both drugs. AMA test results showed that LEV-I caused progression in the developmental stage and an increase in thyroxine level in 7 days exposure and growth retardation in 21 days exposure in stage 51 tadpoles. On the other hand, increases in lactate dehydrogenase activity for both drugs in the AMA test may be due to impacted energy metabolism during sub-chronic exposure. These results also show that the sensitivity and responses of Xenopus laevis at different early developmental stages may be different when exposed to drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据