Disordered serum essential element levels are associated with increased risk of kidney tumors

Essential elements play vital roles in the regulation of carcinogenesis. We aimed to investigate the relationship between essential elements and kidney tumors. This study included 72 healthy individuals and 100 kidney tumor patients. The concentrations of cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), selenium (Se), and zinc (Zn) were determined by inductively coupled plasma mass spectrometry. The random forest model was used to evaluate the importance of each variable by using the randomForest package. The associations between essential elements and clinical tumor characteristics were examined by the Mann-Whitney U-test, and the log-rank test was used to assess the Kaplan-Meier curves. The levels of Co, Cr, Fe, Mn, Ni, and Zn in patients with kidney tumors were significantly lower. In the random forest model, the top two metallic features were Co and Zn. The Kaplan-Meier curve showed that patients with lower Co, Se, and Zn levels exhibited lower progression-free survival. In summary, this study gathered evidence that disordered essential elements are associated with kidney tumors and thus opens a new path to elucidate the etiology of kidney tumors from the perspective of environmental health and safety.

Automated summary

This study investigated the relationship between essential elements and kidney tumors. The results showed that patients with kidney tumors had significantly lower levels of Co, Cr, Fe, Mn, Ni, and Zn, and Co and Zn were identified as the most important metallic features. Additionally, lower levels of Co, Se, and Zn were associated with lower progression-free survival in kidney tumor patients.