期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 55, 期 24, 页码 16502-16514出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.1c04455
关键词
prenatal exposures; vulnerable population; nonpersistent chemicals; endocrine disruptor chemicals; chemical mixtures; neurodevelopment
资金
- National Institutes of Health [R01ES032826, UH3OD023305, R01ES022972, R01ES029779]
- National Institute of Environmental Health Sciences, National Institutes of Health [HHSN273201500003C, ZIAES101575]
- European Union [733206, 874583, 824989]
- Ter Meulen grant [KNAWWF/DA/2016/TMB368]
- LifeCycle fellowship [733206]
- Netherlands Organization for Scientific Research (NWO) VICI grant [NWO-ZonMW: 016. VICI.170.200]
- Miguel Servet fellowship - Spanish Institute of Health Carlos III [CPII18/00018]
- European Research Council [ERC-2014CoG-648916]
- Intramural Research Program of the National Institute of Environmental Health Sciences, National Institutes of Health
- Spanish Ministry of Science and Innovation
- State Research Agency through the Centro de Excelencia Severo Ochoa 2019-2023 Program [CEX2018-000806-S]
- Generalitat de Catalunya through the CERCA Program
Prenatal exposure to nonpersistent chemical mixtures is associated with lower nonverbal IQ in children, but not emotional and behavioral problems. This exposure is universal and may impact neurodevelopment.
Prenatal exposure to nonpersistent chemicals such as phthalates, bisphenols, and organophosphate (OP) pesticides is ubiquitous and occurs in mixtures. So far, epidemiological studies investigating neurodevelopmental consequences of these exposures have mainly been restricted to single-pollutant models. Thus, we studied the association between prenatal exposure to nonpersistent chemical mixtures and child IQ and emotional and behavioral problems. Data came from 782 mother-child pairs. Eleven phthalate, one bisphenol, and five OP pesticide urinary exposure biomarkers were measured three times during pregnancy and averaged. Nonverbal IQ, internalizing and attention problems, aggressive behavior, and autistic traits were assessed at child age 6 years. We used quantile g-computation to estimate the change in each outcome per quartile increase in all chemicals within the mixture. Higher exposure to the mixture was associated with lower nonverbal IQ (-4.0 points (95%CI = -7.0, -1.0), -5.5 points (95%CI = -10.2, -0.9), and -4.6 points (95%CI = -10.8, 1.5) for the second, third, and fourth quartile, respectively, compared to the first quartile). These results were mainly driven by the phthalate mixture. No association was observed with emotional and behavioral problems. Prenatal exposure to nonpersistent chemical mixtures was associated with lower nonverbal IQ in children. Exposure to chemical mixtures during gestation is universal and may impact neurodevelopment.
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