期刊
ENVIRONMENTAL RESEARCH
卷 201, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2021.111585
关键词
Magnetic materials; Cardiospermum halicacabum; Peripheral blood mononuclear cells; Cytotoxicity; ROS scavenging; Brine shrimp assay
资金
- National Research Foundation of Korea by the Korean Government (Ministry of Science and ICT - MSIT) [2020R1G1A1012069]
- National Research Foundation of Korea [2020R1G1A1012069] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study synthesized iron oxide nanoparticles using two different methods and found that these nanoparticles exhibited good biocompatibility, potential antibacterial activity, and low toxicity, making them suitable for various medical applications.
Iron oxide nanoparticles synthesis is an expanding area of research due of their magnetic properties and possible applications in several novel technologies. FeONPs are indispensable in the biomedical field for diagnosis, treatments and drug delivery and in bioremediation applications. The synthesis route of nanoparticles is a major concern because biological methods are eco-friendly, and chemical methods are considered toxic. The objective of this study is to synthesize FeONPs by two different methods and to compare their properties and efficiency in applications. FeONPs were synthesized and characterized by microscopic and various spectroscopic techniques. The synthesized FeONPs were screened for their cytotoxic activity on PBMCs using MTT assay and found to exhibit good biocompatibility. Moreover, the GS FeONPs exhibited potential antibacterial activities and meanwhile showed less toxicity in brine shrimp lethality assay. Hence, these nanoparticles are biocompatible, environmentally safe and can be utilized in many medical applications.
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