期刊
ENVIRONMENTAL CHEMISTRY LETTERS
卷 19, 期 6, 页码 4031-4062出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10311-021-01274-z
关键词
Bacterial vaccine; Viral vaccine; Human vaccination; Herd immunity; Antibiotic resistance; Multidrug resistance
资金
- Pfizer
The dramatic rise in AMR poses a global threat, with vaccines showing promise in reducing resistance but being underutilized.
At present, the dramatic rise in antimicrobial resistance (AMR) among important human bacterial pathogens is reaching a state of global crisis threatening a return to the pre-antibiotic era. AMR, already a significant burden on public health and economies, is anticipated to grow even more severe in the coming decades. Several licensed vaccines, targeting both bacterial (Haemophilus influenzae type b, Streptococcus pneumoniae, Salmonella enterica serovar Typhi) and viral (influenza virus, rotavirus) human pathogens, have already proven their anti-AMR benefits by reducing unwarranted antibiotic consumption and antibiotic-resistant bacterial strains and by promoting herd immunity. A number of new investigational vaccines, with a potential to reduce the spread of multidrug-resistant bacterial pathogens, are also in various stages of clinical development. Nevertheless, vaccines as a tool to combat AMR remain underappreciated and unfortunately underutilized. Global mobilization of public health and industry resources is key to maximizing the use of licensed vaccines, and the development of new prophylactic vaccines could have a profound impact on reducing AMR.
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