期刊
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
卷 40, 期 2, 页码 86-88出版社
EDICIONES DOYMA S A
DOI: 10.1016/j.eimc.2020.09.014
关键词
Synergism; Amphotericin B; Tacrolimus; Cyclosporine A; Cryptococcus spp.
资金
- Brazilian Agencies FAPERGS [2261-12]
This study evaluated the in vitro activity of tacrolimus and cyclosporine in combination with amphotericin B and fluconazole against C. neoformans, and found that these drug combinations showed synergistic effects against certain isolates, potentially offering novel therapeutic strategies for this opportunistic mycosis.
Introduction: Infections caused by Cryptococcus neoformans are a major cause of fungal mortality in HIVinfected/AIDS patients and in those receiving organ transplants. We evaluated the in vitro activity of tacrolimus and cyclosporine in combination with amphotericin B and fluconazole against C. neoformans. Methods: MICs were determined against a total of 30 clinical isolates of C. neoformans by the microdilution method following the CLSI M27-A3 guidelines and by the checkerboard method. Results: Tacrolimus and cyclosporine A showed in vitro activity against cryptococcal isolates. The combination of amphotericin B with cyclosporine A or tacrolimus was synergistic against 90% and 30% of isolates, respectively. Synergism was also observed with the combination of fluconazole with cyclosporine A or tacrolimus, against 70% and 20% of isolates, respectively. Conclusions: The synergistic interactions between the calcineurin inhibitors and antifungal drugs against C. neoformans isolates, could potentially have a role in devising novel therapeutic strategies for this opportunistic mycosis. (C) 2020 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved.
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