4.7 Article

PI4-kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum

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Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii

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Summary: In this study, we demonstrate that the protein kinase TgCDPK7 regulates cellular processes such as vesicular trafficking and phospholipid synthesis, critical for the development of the parasite Toxoplasma gondii. It phosphorylates the small GTPase TgRab11a to regulate the trafficking of important parasite proteins, crucial for parasite division. TgCDPK7 may also regulate key enzymes involved in the biogenesis of phosphatidylethanolamine, contributing to the synthesis of this important phospholipid. These findings shed light on a novel signaling pathway in apicomplexan parasite Toxoplasma gondii.

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