期刊
EMBO MOLECULAR MEDICINE
卷 13, 期 12, 页码 -出版社
WILEY
DOI: 10.15252/emmm.202013452
关键词
gut microbiota; inflammasome; interleukin 18; interleukin 1 beta
资金
- Uehara Memorial Foundation grants of Overseas Postdoctoral Fellowships
- Japan Society for the Promotion of Science grants of Postdoctoral Fellowships for Research Abroad
- National Natural Science Foundation of China [82070546]
- National Institutes of Health [DK108901, DK119219, AI142047, DK125087]
The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death by detecting microbial and endogenous stimuli, leading to the release of pro-inflammatory cytokines or cell death. Interactions between gut microbiota and the inflammasome have significant impacts on gastrointestinal homeostasis and disease progression.
The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation. The activation of caspases results in the maturation of pro-inflammatory cytokines IL-1 beta and IL-18 or pyroptosis. Inflammasome dysfunction is associated with the pathogenesis of various diseases, including autoimmune disease and cancer. It appears that the interactions between the gut microbiota and the inflammasome play crucial roles in the gastrointestinal tract. The gut microbiota induces the expression and activation of inflammasome proteins, which contribute to both homeostasis and disease in the gut. Likewise, although controversial, mounting evidence suggests that inflammasome activation can modulate the composition of the gut microbiota, which, in turn, affects disease progression. In this review, we summarize the current concepts and recent insights linking the inflammasome and gut commensal microorganisms. We describe how the reciprocal interaction between the inflammasome and the commensal microbiota relates to physiological and pathophysiological consequences in the host.
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