Fluidity is the way to life: lipid phase separation in bacterial membranes

Article Biochemistry & Molecular Biology

Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria

Marvin Gohrbandt et al.

Summary: Living organisms adjust their membrane lipid composition in response to changes in their environment or diet. Understanding the key concepts of membrane biology linked to regulation of lipid composition is crucial, and in vitro studies have been relied upon heavily. However, research using bacterial organisms has shown that inadequate in vivo membrane fluidity can interfere with essential cellular processes, and very low membrane fluidity can trigger lipid phase separation and protein segregation in living cells.

EMBO JOURNAL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Yeast cells actively tune their membranes to phase separate at temperatures that scale with growth temperatures

Chantelle L. Leveille et al.

Summary: Membrane phase separation in vacuoles of budding yeast during the cell's growth cycle is regulated by physical conditions and is essential for yeast survival. The transition temperature of phase separation is adapted by cells to maintain proximity to the transition. Depletion of ergosterol, the major sterol in yeast, leads to the formation of membrane domains, contradicting previous assumptions.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Biology