期刊
EMBO JOURNAL
卷 41, 期 6, 页码 -出版社
WILEY
DOI: 10.15252/embj.2021109845
关键词
endoplasmic reticulum; ERAD; protein degradation; protein quality control; ubiquitin ligase
资金
- Senior Cancer Research Fellowship from Cancer Research UK [C68569/A29217]
- Wellcome [202642/Z/16/Z]
- European Research Council Consolidator grant [817708]
- Wellcome Trust [202642/Z/16/Z] Funding Source: Wellcome Trust
- European Research Council (ERC) [817708] Funding Source: European Research Council (ERC)
This article discusses recent advances in understanding the mechanisms of ERAD and its impact on the regulation of ER functions.
The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER protein homeostasis is essential for the coordination of its diverse functions and depends on ER-associated protein degradation (ERAD). The latter process selects target proteins in the lumen and membrane of the ER, promotes their ubiquitination, and facilitates their delivery into the cytosol for degradation by the proteasome. Originally characterized for a role in the degradation of misfolded proteins and rate-limiting enzymes of sterol biosynthesis, the many branches of ERAD now appear to control the levels of a wider range of substrates and influence more broadly the organization and functions of the ER, as well as its interactions with adjacent organelles. Here, we discuss recent mechanistic advances in our understanding of ERAD and of its consequences for the regulation of ER functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据