4.5 Article

Nontargeted screening of veterinary drugs and their metabolites in milk based on mass defect filtering using liquid chromatography-high-resolution mass spectrometry

期刊

ELECTROPHORESIS
卷 43, 期 18-19, 页码 1822-1831

出版社

WILEY
DOI: 10.1002/elps.202100296

关键词

Liquid chromatography-high-resolution mass spectrometry; Mass defect filtering; Nontargeted screening; Veterinary drugs

资金

  1. National Key Program [2018YFC1602400, 2019YFC1605100]
  2. National Natural Science Foundation of China [21974140, 21874132, 22174141]
  3. Innovation Program of Science and Research from Dalian Institute of Chemical Physics, Chinese Academy of Sciences [DICP I202108, DICP I202004]

向作者/读者索取更多资源

A nontargeted screening strategy based on mass defect filtering (MDF) was developed for veterinary drugs. Three MDF models were established and applied to screen veterinary drugs in milk samples, identifying four veterinary drugs and six drug metabolites. This strategy effectively removes interfering substances and can be used for nontargeted screening in other food matrices.
The development of nontargeted screening strategy for veterinary drugs and their metabolites is very important for food safety. In this study, a nontargeted screening strategy was developed to find the potentially hazardous substances based on mass defect filtering (MDF) using liquid chromatography-high-resolution mass spectrometry. First, the drug metabolites of 112 veterinary drugs from seven classes of antimicrobials were predicted. Second, three MDF models were established, including the traditional rectangular MDF, the enhanced parallelogram MDF, and the polygonal MDF. Finally, the strategy was applied to nontargeted screening of veterinary drugs in 36 milk samples. The polygonal MDF model based on the distribution area of parent drugs and their metabolites showed a better filtering effect. After removing food components and performing MDF, about 10% of the substances remained, and four veterinary drugs and six drug metabolites were discovered and identified, showing the effectiveness of this strategy. The nontargeted screening strategy can rapidly remove interfering substances and find the suspected compounds. It can also be used for nontargeted screening of veterinary drugs and their metabolites in other food matrices.

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