期刊
ELECTROCHIMICA ACTA
卷 405, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2022.139837
关键词
Antibiotic resistance; Acinetobacter baumannii; Drug repurposing; Electroanalysis; Biofilm; Fungicides
资金
- Faculty Development Competitive Research Grant Program [110119FD4537]
- School of Engineering and Digital Sciences, Nazarbayev University, Kazakhstan
- Collaborative Research Program, Nazarbayev University, Kazakhstan [021220CRP0522]
Drug repurposing is an immediate approach to fight antibiotic resistant pathogens, and antifungal drugs are good candidates for it. This study determined the activity of two antifungal drugs against Acinetobacter baumannii biofilms using bioelectrochemical methods and provided the basis for implementing these methods in clinical antimicrobial testing.
Drug repurposing, which entails the use of established drugs to treat infections and ailments for which they were not originally developed for, is an immediate approach to fight antibiotic resistant pathogens. Antifungal drugs are good candidates for drug repurposing, due to their well-understood mechanism of action and low host toxicity. Acinetobacter baumannii is a common nosocomial pathogen with diverse virulence factors and broad-spectrum antibiotic resistance, resulting in high morbidity and mortality rates, especially as biofilm. Thus, repurposing of fungicides for control of A. baumannii biofilm is worth investigating. It is also pertinent to devise means for rapid characterization of antibiofilm effects of repurposed drugs. In this study, the activity of two antifungal drugs against A. baumannii biofilms is determined on screen-printed electrodes (SPE) through chronoamperometry. The tested fungicides - itraconazole and fluconazole - mitigated the formation of early A. baumannii biofilms, as determined by biochemical, electrochemical, and microscopic analysis. This work shows that bioelectrochemical methods can be used for continuous and non-destructive assessment of the antibiofilm activity of fungicides and provides the basis for implementation of bioelectrochemical methods in clinical antimicrobial testing. (c) 2022 Elsevier Ltd. All rights reserved.
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