期刊
ELECTROANALYSIS
卷 34, 期 7, 页码 1114-1120出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.202100570
关键词
Colistimethate sodium; Liposome; Encapsulation; Electrochemical Detection; Differential Pulse Voltammetry; Cyclic Voltammetry
资金
- Izmir Katip Celebi University Scientific Research Projects Coordination Unit [2019-GAP-ECZF-0005]
In this study, the electrochemical quantification of CMS released from liposomes was achieved for the first time. The cationic liposome showed higher encapsulation efficiency and controlled release with zero-order drug release kinetics.
In this study, the neutral and cationic liposomal formulations of Colistimethate sodium (CMS), an antibiotic for multi-drug resistant gram-negative bacteria, were prepared and electrochemical quantification of CMS from these liposomes were achieved. This is the first study of the electrochemical detection of CMS released from liposomes. First, the electrochemical properties of CMS were analysed, then the encapsulation efficiency, and the release kinetic of CMS from liposomes were determined with Differential Pulse Voltammetry (DPV) measurements. In addition, Cyclic Voltammetry were applied to determine oxidation signal of CMS. A higher encapsulation efficiency was found in the cationic liposome compared to the neutral liposome. Moreover, CMS was controlled released from liposomes with zero-order drug release kinetics.
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