期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 223, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112605
关键词
Organophosphorus flame retardants; Tris (13-dichloroisopropyl) phosphate; Triphenyl phosphate; Oryzias melastigma; Chronic toxicity; Developmental toxicity
资金
- National Natural Science Founda-tion of China [41676094]
The study showed that TDCIPP and TPhP have developmental toxicity in marine organisms, leading to shortened body length, fin deformities, and spinal curvature in Oryzias melastigma, posing potential risks to marine fish and ecosystems. Additionally, although both chemicals caused similar bone toxicity, they had different effects on the expression of bone developmental genes such as bmp4, bmp2, and runx2.
The global phase-out has decreased the use of polybrominated diphenyl ethers (PBDEs), thereby, rapidly increasing the production and use of their important surrogates, organophosphorus flame retardants (OPFRs). Currently, OPFRs are often found at higher levels in the environments compared to PBDEs. Although the two typical OPFRs, tris (1,3-dichloroisopropyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP), have been frequently detected in marine environments with significant concentrations, their toxicity to marine organisms remains unknown. We used Oryzias melastigma to investigate and compare their developmental toxicity in marine organisms through two-generational chronic exposure. The results showed that TDCIPP and TPhP exposure shortened the body length and length of the pectoral fin of O. melastigma. Both TDCIPP and TPhP deformed the pectoral fins in the 1st fry and caused spinal curvature in adult fish. Therefore, these two chemicals may pose potential risks to marine fish and marine ecosystems. Further studies suggested that although these two chemicals caused similar developmental bone toxicity, they had different modes of modulating the expression of bone developmental genes such as, bmp4, bmp2 and runx2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据