期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 225, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112760
关键词
Obesity; Inflammation; Oxidative stress; Apoptosis; Escherichia coli; Heart
资金
- Program for Changjiang Scholars
- University Innovative Research Team [IRT 0848]
- Fundamental Research Funds for the Central Universities, Southwest Minzu University [2020NQN34]
The study investigated the relationship between obesity and heart health during non-fatal bacterial infection, finding that while infection led to cardiac inflammation, oxidative stress, and excessive apoptosis, obesity had a mitigating effect on these negative impacts.
Obesity is a risk factor of many diseases, but could be beneficial to the individuals with bacterial infection. The present study was conducted to investigate the relationship between obesity and heart during nonfatal bacterial infection. Male normal (lean) and diet-induced obesity mice (DIO, fed with high-fat diet) were chosen to perform nasal instillation with E. coli to establish a nonfatal acute mouse model. The cardiac histopathology, inflammation and oxidative damage, as well as apoptosis were detected post-infection. The results revealed that the Escherichia coli (E.coli)-infected mice exhibited increased cardiac index, contents of IL-1 beta, IL-6, IL-8, TNF-alpha, leptin and resistin, levels of apoptotic proteins (caspase-3 and caspase-9, and bax/bcl-2 ratio), cardiac pathological changes and oxidative stress. Furthermore, these parameters were more serious in the lean mice than those in the DIO mice. In summary, our findings gave a new sight that E.coli infection impaired heart via histopathological lesions, inflammation and oxidative stress and excessive apoptosis of cardiomyocytes. Interestingly, obesity exerted attenuated effects on the heart of mice with non-fatal infection of E.coli through decreased inflammation, oxidative stress and apoptosis of cardiac tissue.
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