4.7 Article

Effect of copper nanoparticles and copper ions on the architecture of rainbow trout olfactory mucosa

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Summary: The study found that CuNPs are bioavailable to olfactory mucosal cells and have different effects on rainbow trout compared to Cu2+. RNA-seq analysis revealed distinct mechanisms of action between the two contaminants, with CuNPs affecting olfactory signal transduction, calcium homeostasis, and synaptic vesicular signaling in OSNs. CuNPs also impacted neuroregenerative pathways and suppressed inflammatory signaling, without inducing oxidative stress or apoptosis.

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