4.7 Article

A fluorescent nanoprobe based on AIEgen: Visualization of silver ions and sensing applications in cancer cells and S. aureus

期刊

DYES AND PIGMENTS
卷 198, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.110027

关键词

Fluorescent probe; Silver ion; Aggregation-induced emission; 2-(methylthio)aniline moiety; Fluorescent imaging

资金

  1. National Research Foundation (NRF) of Korea - Ministry of Education [NRF-2018-R1A6A1A03025124, NRF-2018-R1D1A1B07043383]
  2. Bio & Medical Technology Devel-opment Program of the NRF of Korea - Ministry of Science ICT [NRF-2019-M3A9H1103783]
  3. Korea Health Technology R&D Project of the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI21C0239]
  4. Bio & Medical Technology Development Program of the NRF of Korea [NRF-2021-M3A9I5030523]
  5. Interne Fondsen KU Leuven/Internal Funds KU Leuven [STG/19/029]

向作者/读者索取更多资源

The fluorescent nanoprobe AgP-1 has been developed for detecting silver ions in biological media, showing high selectivity, sensitivity, and significant fluorescence enhancement upon forming complex with silver ions. The probe also demonstrates fast response time and superior biocompatibility, with successful visualization of silver ions in cancer cells and bacteria. This indicates the potential of AgP-1 as a practical sensor for silver ions detection in biomedical applications.
We have developed a fluorescent nanoprobe (AgP-1) that can detect silver ions (Ag+) in biological media. For the first time, a hybridized structure based on AIEgen (tetraphenylethylene; TPE) and 2-(methylthio)aniline (MTA) moiety has been designed, and its unique sensing properties toward silver ions were systematically analyzed. The nanoprobe AgP-1 has an aggregated form with weak fluorescence and showed significant fluorescence enhancement (3.7-fold) upon forming complex with silver ions. AgP-1 has high selectivity, high sensitivity (detection limit 6.6 ppb), a fast response time (fluorescence enhancement within 10 s), and superior biocompatibility. Visualization of silver ions in cancer cells (U87 glioblastoma) and bacteria (S. aureus) was also successfully demonstrated. We believe AgP-1 holds a great potential to serve as a practical sensor for silver ions detection in biomedical applications.

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