期刊
DYES AND PIGMENTS
卷 194, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109570
关键词
COVID-19; SARS-CoV-2 inactivation; Photodynamic; Photosensitizer
资金
- National Key R&D Program of China [2017YFE0103200]
- National Natural Science Foundation of China [31670739, 22077016, 82070142, 31870163]
- Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) [XDB29010102]
- NSFC Outstanding Young Scholars [31822055]
- Youth Innovation Promotion Association of CAS [2017122]
The study discovered two compounds that can effectively inhibit the infection and replication of the novel coronavirus in vitro. These compounds were identified through screening of photosensitizers and have unique advantages such as resistance to virus mutations, affordability, and lack of long-term toxicity.
The ongoing pandemic of coronavirus disease 2019 (COVID-19) posed a major challenge to the public health. Currently, no proven antiviral treatment for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is available. Here we report compounds pentalysine beta-carbonylphthalocyanine zinc (ZnPc5K) and chlorin e6 (ce6) potently inhibited the viral infection and replication in vitro with EC50 values at nanomolar level. These compounds were first identified by screening a panel of photosensitizers for photodynamic viral inactivation. Such viral inactivation strategy is implementable, and has unique advantages, including resistance to virus mutations, affordability compared to the monoclonal antibodies, and lack of long-term toxicity.
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