期刊
DYES AND PIGMENTS
卷 197, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109870
关键词
Chemical warfare agents; G-series nerve agents; Squaraine; Nucleophilic addition; Colorimetric detection
资金
- Natural Science Foundation of China [22172097, 21820102005, 22002081]
- 111 project [B14041]
- Innovation Capability Support Program of Shaanxi [2021TD-18]
- Fundamental Research Funds for the Central Universities of China [GK202001005, GK202003034]
- China Postdoctoral Science Foundation [2020M683418]
- State Key Laboratory of NBC Protection for Civilian [SKLNBC2020-20]
- Youth Innovation Team of Shaanxi Universities
A chemical approach based on the squaraine-ethanolamine (SQ-ETA) adducts has been developed for rapid and sensitive detection of G-series nerve agents and simulants. The method features turn-on response and colorimetric mode, and can be used for semi-quantitative evaluation with the help of smartphone-based analytical methodology.
High toxicity and reactivity of chemical warfare agents (CWAs) have attracted increasing demand of reliable detection methods for countering terrorism. Herein, we report a chemical approach based on the squaraine-ethanolamine (SQ-ETA) adducts for rapid, sensitive, and selective detection of the G-series nerve agents and simulants in aqueous media. Present strategy features the merits of obvious turn-on response and colorimetric mode upon the presence of certain analytes. Possible sensing mechanism was the nucleophilic addition of ethanolamine toward the central SQ core to generate a SQ-ETA adduct firstly, supported by the additional NMR and MS characterizations. And special binding affinity of the G-series nerve agents and simulants to the hydroxyl groups in the SQ-ETA adducts thus recover the original SQs (SQOH and SQPY), endowing distinguishable colorless-to-blue change. The detection limits for diethyl chlorophosphate and diethyl cyanophosphonate were determined from the SQOH-ETA system to be 3.5 and 36.0 mu M, respectively. In addition, the obtained adducts were further utilized to detect real G-series nerve agents including sarin (GB) and soman (GD), confirming the strategy suitable for on-site detection. In conjunction with smartphone-based analytical methodology, proper correlation between the RGB changes and substance concentrations was founded. Present successful trials inspire the semi-quantitative evaluation of G-series nerve agents with high accuracy and relative simplicity, implying great potential in detecting CWAs.
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