期刊
DYES AND PIGMENTS
卷 194, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109589
关键词
Tetraphenylporphyrin; Protonation; Solubilization; Dodecyl sulfate; Nafion; pH-dependent fluorescence
资金
- RFBR (Russian Foundation for Basic Research) [18-03-01104]
This study introduces a pH-controlled solubilization technique for hydrophobic porphyrin photosensitizers, utilizing anionic amphiphilic nanoparticles, which show increased fluorescence in acidic tumor microenvironments. This concept demonstrates the potential of pH-dependent off-on photosensitizers for photodynamic theranostics, with high fluorescence and phototoxicity within tumors and low toxicity in normal tissues.
pH-controlled solubilization technique for hydrophobic porphyrin photosensitizers, which tetrapyrrole platform is a pH-dependent anion-molecular receptor, using anionic amphiphilic nanoparticles is proposed. Water-soluble forms of tetraphenylporphyrin were made as the complexes with sodium dodecyl sulfate micelles H2P(Ph)4/ (NaDS)64 and with nanoparticles of biocompatible polysulfonate Nafion DE 1020 H2P(Ph)4/NNP. Diprotonation of these complexes leads to the fluorescence enhancement in the therapeutic window spectral region, and the integral intensity exceeds the value for the PDT drug Fotoditazin (R). A unique feature of the excited complex H2P (Ph)4/NNP is the shift of its protonation equilibrium to the physiological pH value of healthy tissues. This pH value is the starting point of pH-induced H2P(Ph)4/NNP fluorescence increasing. In the pH range, corresponds to the acidic tumors microenvironment, integral fluorescence of H4P2+(Ph)4/NNP increases to 250%, which is quarter of the maximum fluorescence value. These results demonstrate the possibility and the concept of pHdependent off-on photosensitizers for photodynamic theranostics based on H2P(Ph)4 derivatives, with low fluorescence and phototoxicity in normal tissues and high fluorescence and phototoxicity inside the tumor microenvironment.
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