High efficiency branched thermal activated delayed fluorescent probe based on cyanogroup for detecting Fe3+with low limit of detection

A multipolarization branched thermal activated delayed fluorescence sensor BrACCN was designed and synthesized based on cyano-carbazole. The classical molecule structure 4CzCN was used as luminescent nucleus, which was progressively branched for photophysical optimization. On the basis of the thermal activated delayed fluorescence material 4CzCN and 4Cz-CzCN, the molecular modification was optimized to achieve long fluorescence life and high quantum yield. Through research and analysis, the fluorescence quantum yield of the branched probe was 73%, which was 1.5 times higher than that of unbranched 4CzCN. The fluorescence lifetime of the probe BrACCN was doubled up to 3 Its based on the introduction of peripheral Br atoms. Meanwhile, the probe has high selectivity and sensitivity for Fe3+ ions. In the presence of multiple ions, the probe responded only to Fe3+ with a complexing mode of 1:1 and the fluorescence was turned off. The probe has a low limit of detection (LOD) of 2.9 x 10-8 mol/L for Fe3+ ions. The probe also has a strong AIE characteristic, which is extremely beneficial for the application range of the probe. Moreover, these excellent properties of the probe will offer promising applications in live-cell confocal fluorescence imaging and time-resolved fluorescence imaging.

Automated summary

A multipolarization branched thermal activated delayed fluorescence sensor, based on cyano-carbazole, was designed and synthesized. The probe showed long fluorescence life, high quantum yield, high selectivity and sensitivity for Fe3+ ions, and a low limit of detection. It also exhibited strong aggregation-induced emission, making it potentially useful for live-cell confocal fluorescence imaging and time-resolved fluorescence imaging.