4.6 Review

Mechanisms, Management and Prevention of Pemetrexed-Related Toxicity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Rethinking the Application of Pemetrexed for Patients with Renal Impairment: A Pharmacokinetic Analysis

Nikki de Rouw et al.

Summary: Population pharmacokinetic analysis of pemetrexed showed that renal function significantly influences drug clearance, with up to 84% of total clearance attributed to renal function. This finding highlights the importance of considering renal impairment in patients receiving pemetrexed therapy. Additionally, a three-compartment model may contribute to prolonged drug exposure during elimination phases.

CLINICAL PHARMACOKINETICS (2021)

Article Oncology

Toxicity of pemetrexed during renal impairment explained-Implications for safe treatment

Rene J. Boosman et al.

Summary: Pemetrexed is an important component in the first-line treatment of patients with non-squamous non-small cell lung cancer, but its use is limited in patients with renal impairment due to hematological toxicity. Research aimed to explore the relationship between pemetrexed exposure and toxicity in renal impairment patients, finding that the approved dose may result in a high probability of severe neutropenia in this population, suggesting the need for alternative dosing regimens for safe administration.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Medicine, General & Internal

Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer

L. Gandhi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Single-dose dexamethasone for the prevention of pemetrexed associated cutaneous adverse reactions

Raymond Elsoueidi et al.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2016)

Article Oncology

Management of febrile neutropaenia: ESMO Clinical Practice Guidelines

J. Klastersky et al.

ANNALS OF ONCOLOGY (2016)

Article Oncology

Preventing and Managing Toxicities of High-Dose Methotrexate

Scott C. Howard et al.

ONCOLOGIST (2016)

Article Pharmacology & Pharmacy

Pemetrexed-Induced Rash May Be Prevented by Supplementary Corticosteroids

Takumi Sakurada et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)

Article Urology & Nephrology

Onco-Nephrology: Renal Toxicities of Chemotherapeutic Agents

Mark A. Perazella

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Article Oncology

The Antifolates

Michele Visentin et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2012)

Article Pharmacology & Pharmacy

Toxic Epidermal Necrolysis and Antifolate Drugs in Cancer Chemotherapy

Claudine Pierard-Franchimont et al.

CURRENT DRUG SAFETY (2012)

Article Oncology

Skin Toxicities Compromise Prolonged Pemetrexed Treatment

Belen Eguia et al.

JOURNAL OF THORACIC ONCOLOGY (2011)

Review Oncology

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

Shrikanta Chattopadhyay et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Proceedings Paper Imaging Science & Photographic Technology

FMOE-MR: Content-driven multi-resolution MPEG-4 fine grained scalable layered video encoding

S. Chattopadhyay et al.

MULTIMEDIA COMPUTING AND NETWORKING 2007 (2007)

Review Oncology

The pathobiology of mucositis

ST Sonis

NATURE REVIEWS CANCER (2004)

Review Oncology

Molecular, biochemical, and cellular pharmacology of pemetrexed

ID Goldman et al.

SEMINARS IN ONCOLOGY (2002)

Article Urology & Nephrology

The folate cycle and disease in humans

B Fowler

KIDNEY INTERNATIONAL (2001)

Article Oncology

Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation

JD Roberts et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2000)