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Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase
Jiang-Kai Dong et al.
THERANOSTICS (2018)
Stem Cell Metabolism in Cancer and Healthy Tissues: Pyruvate in the Limelight
Cyril Corbet
FRONTIERS IN PHARMACOLOGY (2018)
Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
Elena Gazzano et al.
FRONTIERS IN PHARMACOLOGY (2018)
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Sebastian Brachtendorf et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
Association of tamoxifen resistance and lipid reprogramming in breast cancer
Susanne Hultsch et al.
BMC CANCER (2018)
Translational and HIF-1 alpha-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
Laura Hulea et al.
CELL METABOLISM (2018)
Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
Kevin D. Courtney et al.
CELL METABOLISM (2018)
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
Maria Apicella et al.
CELL METABOLISM (2018)
Carbonic Anhydrase XII Inhibitors Overcome P-Glycoprotein-Mediated Resistance to Temozolomide in Glioblastoma
Iris C. Salaroglio et al.
MOLECULAR CANCER THERAPEUTICS (2018)
Histidine catabolism is a major determinant of methotrexate sensitivity
Naama Kanarek et al.
NATURE (2018)
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
Andrew M. Intlekofer et al.
NATURE (2018)
Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
Martin Benej et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
Austin Yeon et al.
THERANOSTICS (2018)
Activation of LXR?/ by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer
Soochi Kim et al.
BMC CANCER (2018)
Modulating ROS to overcome multidrug resistance in cancer
Qingbin Cui et al.
DRUG RESISTANCE UPDATES (2018)
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma
Lan B. Hoang-Minh et al.
EMBO JOURNAL (2018)
Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
Priyamvada Jayaprakash et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
The role of cellular reactive oxygen species in cancer chemotherapy
Haotian Yang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin
Xueyan Zhang et al.
LIFE SCIENCES (2018)
Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
Benny Zhitomirsky et al.
CELL DEATH & DISEASE (2018)
Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment
Ilze Mentoor et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes
Mariantonia Logozzi et al.
CANCERS (2018)
The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
Saima Kausar et al.
CELLS (2018)
The Influence of Metabolism on Drug Response in Cancer
Esther A. Zaal et al.
FRONTIERS IN ONCOLOGY (2018)
Oxamate, but Not Selective Targeting of LDH-A, Inhibits Medulloblastoma Cell Glycolysis, Growth and Motility
Cara J. Valvona et al.
BRAIN SCIENCES (2018)
Statin drugs to reduce breast cancer recurrence and mortality
Colin H. Beckwitt et al.
BREAST CANCER RESEARCH (2018)
NF-kappa B Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy
Paula Grondona et al.
BIOMEDICINES (2018)
Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2017)
Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
T. Yu et al.
ONCOGENE (2017)
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
Haifeng Wang et al.
ONCOLOGY LETTERS (2017)
PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
Mi-Jin Kim et al.
MOLECULAR CANCER RESEARCH (2017)
Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma
Fumihito Noguchi et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non-Small Cell Lung Cancer Cells
Kayleigh C. Ross et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway
Xueyan Zhang et al.
MOLECULAR MEDICINE REPORTS (2017)
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Prasenjit Dey et al.
NATURE (2017)
Glucose feeds the TCA cycle via circulating lactate
Sheng Hui et al.
NATURE (2017)
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Vasanthi S. Viswanathan et al.
NATURE (2017)
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M. Kuntz et al.
NATURE MEDICINE (2017)
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer
V. Thewes et al.
ONCOGENE (2017)
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
Pasquale Sansone et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Therapeutic implications of tumor interstitial acidification
Iryna Kolosenko et al.
SEMINARS IN CANCER BIOLOGY (2017)
The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells
Joana Balca-Silva et al.
TRANSLATIONAL ONCOLOGY (2017)
MICU1 drives glycolysis and chemoresistance in ovarian cancer
Prabir K. Chakraborty et al.
NATURE COMMUNICATIONS (2017)
NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
Karthigayan Shanmugasundaram et al.
NATURE COMMUNICATIONS (2017)
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge et al.
CANCER DISCOVERY (2017)
Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells
Ravyn M. Thompson et al.
ONCOTARGET (2017)
Mitochondrial power drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer
Marco Fiorillo et al.
ONCOTARGET (2017)
Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer
Medhi Wangpaichitr et al.
ONCOTARGET (2017)
11C-Methionine-PET in Multiple Myeloma: A Combined Study from Two Different Institutions
Constantin Lapa et al.
THERANOSTICS (2017)
Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells
F. Pepe et al.
ONCOGENESIS (2017)
The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
Kate L. Hertweck et al.
FRONTIERS IN ONCOLOGY (2017)
De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Saber Tadros et al.
CANCER RESEARCH (2017)
Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer
Yunshu Lu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy
Mounia Beloueche-Babari et al.
CANCER RESEARCH (2017)
Lactate Metabolism in Human Lung Tumors
Brandon Faubert et al.
CELL (2017)
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts
Christopher R. Marlein et al.
BLOOD (2017)
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-Min Lee et al.
CELL METABOLISM (2017)
Tumour acidosis: from the passenger to the driver's seat
Cyril Corbet et al.
NATURE REVIEWS CANCER (2017)
Targeting Metabolism for Cancer Therapy
Alba Luengo et al.
CELL CHEMICAL BIOLOGY (2017)
Low Tumor Mitochondrial DNA Content Is Associated with Better Outcome in Breast Cancer Patients Receiving Anthracycline-Based Chemotherapy
Marjolein J. A. Weerts et al.
CLINICAL CANCER RESEARCH (2017)
Bortezomib resistance in multiple myeloma is associated with increased serine synthesis
Esther A. Zaal et al.
CANCER & METABOLISM (2017)
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
Eytan M. Stein et al.
BLOOD (2017)
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka et al.
CHEMICAL REVIEWS (2017)
Metabolic synthetic lethality in cancer therapy
Vincent Zecchini et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Surendra K. Shukla et al.
CANCER CELL (2017)
Emerging roles of lipid metabolism in cancer progression
Cyril Corbet et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2017)
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Yiqun Zhang et al.
CANCER CELL (2017)
Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis
Benjamin Ruprecht et al.
CANCER RESEARCH (2017)
AMPK signalling in health and disease
David Carling
CURRENT OPINION IN CELL BIOLOGY (2017)
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Padmanee Sharma et al.
CELL (2017)
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
Ibtissam Marchiq et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2016)
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
Franziska Baenke et al.
MOLECULAR ONCOLOGY (2016)
Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
Ruxanda Moschoi et al.
BLOOD (2016)
Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
Alina Filatova et al.
CANCER RESEARCH (2016)
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley et al.
CELL (2016)
Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer
D. S. Matassa et al.
CELL DEATH AND DIFFERENTIATION (2016)
Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
Cyril Corbet et al.
CELL METABOLISM (2016)
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Shawn M. Davidson et al.
CELL METABOLISM (2016)
Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
Haobin Ye et al.
CELL STEM CELL (2016)
Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy
Zhiyu Wang et al.
CURRENT DRUG TARGETS (2016)
Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics
Ruud H. Wijdeven et al.
DRUG RESISTANCE UPDATES (2016)
Lysosomes as mediators of drug resistance in cancer
Benny Zhitomirsky et al.
DRUG RESISTANCE UPDATES (2016)
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Wen Li et al.
DRUG RESISTANCE UPDATES (2016)
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
Gao Zhang et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
Jing Liu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)
Evaluation of Prostate Cancer with 11C-Acetate PET/CT
Claudio Spick et al.
JOURNAL OF NUCLEAR MEDICINE (2016)
Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism
G. P. Soriano et al.
LEUKEMIA (2016)
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model
Cecile Gstalder et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Cristovao M. Sousa et al.
NATURE (2016)
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading
Fabricio Loayza-Puch et al.
NATURE (2016)
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Andrew W. Roberts et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Konstantinos J. Mavrakis et al.
SCIENCE (2016)
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
Claudio Vernieri et al.
CANCER DISCOVERY (2016)
Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Paola Pellegrini et al.
ONCOTARGET (2016)
Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
Joanna Kopecka et al.
ONCOTARGET (2016)
MPC1, a key gene in cancer metabolism, is regulated by COUP-TFII in human prostate cancer
Leiming Wang et al.
ONCOTARGET (2016)
Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
Sofia Avnet et al.
ONCOTARGET (2016)
Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients
Gabriela Jimenez-Valerio et al.
CELL REPORTS (2016)
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
Elizabeth Allen et al.
CELL REPORTS (2016)
Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
Laura Pisarsky et al.
CELL REPORTS (2016)
ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
Sunghee Park et al.
CELL REPORTS (2016)
Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide
Joseph E. Ippolito et al.
PLOS ONE (2016)
ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line
Andrea Turbuck Celestino et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma
Yufeng Wu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
Khalid O. Alfarouk et al.
CANCER CELL INTERNATIONAL (2015)
Application of Evolutionary Principles to Cancer Therapy
Pedro M. Enriquez-Navas et al.
CANCER RESEARCH (2015)
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Kivanc Birsoy et al.
CELL (2015)
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho et al.
CELL (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
Patricia Sancho et al.
CELL METABOLISM (2015)
SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
Thomas T. Vellinga et al.
CLINICAL CANCER RESEARCH (2015)
Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer
Viviana De Rosa et al.
CLINICAL CANCER RESEARCH (2015)
Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach
Sophie Taylor et al.
DRUG RESISTANCE UPDATES (2015)
Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism
Helena Joyce et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2015)
Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment
Ganesh Venkatraman et al.
FASEB JOURNAL (2015)
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
Kazuhiro Tanaka et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
Katherine Sellers et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
The Role of C/EBP-β LIP in Multidrug Resistance
Chiara Riganti et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
Jenny E. Hernandez-Davies et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
Drug transporters play a key role in the complex process of Imatinib resistance in vitro
Raquel Alves et al.
LEUKEMIA RESEARCH (2015)
Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald et al.
NATURE (2015)
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng et al.
NATURE (2015)
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
Daniel Herranz et al.
NATURE MEDICINE (2015)
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells
F. Lozupone et al.
ONCOGENE (2015)
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Sriram Venneti et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles
Diana Sousa et al.
TRENDS IN MOLECULAR MEDICINE (2015)
Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation
Annemarie Greife et al.
TUMOR BIOLOGY (2015)
Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
Daniela Catanzaro et al.
ONCOTARGET (2015)
Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
Yali Zhong et al.
ONCOTARGET (2015)
Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells
Joanna Kopecka et al.
ONCOTARGET (2015)
Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
Rikke B. Holmgaard et al.
CELL REPORTS (2015)
Signal Transduction in Cancer
Richard Sever et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers
James B. Stewart et al.
PLOS GENETICS (2015)
The Role of C/EBP-β LIP in Multidrug Resistance
Chiara Riganti et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
2-Deoxy-D-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells
Shuo-Yu Wang et al.
PLOS ONE (2015)
Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
Benny Zhitomirsky et al.
ONCOTARGET (2015)
Tumorigenesis: it takes a village
Doris P. Tabassum et al.
NATURE REVIEWS CANCER (2015)
Cancer Metabolism and Drug Resistance
Mahbuba Rahman et al.
METABOLITES (2015)
Collateral Lethality: A New Therapeutic Strategy in Oncology
Florian L. Muller et al.
TRENDS IN CANCER (2015)
Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
Rakesh K. Pathak et al.
ACS CHEMICAL BIOLOGY (2014)
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype
Shiva Kant et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
Targeting cisplatin-resistant human tumor cells with metabolic inhibitors
Elizabeth J. Sullivan et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2014)
The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Cyril Corbet et al.
CANCER RESEARCH (2014)
Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Tomoyuki Mashimo et al.
CELL (2014)
Cisplatin in cancer therapy: Molecular mechanisms of action
Shaloam Dasari et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Therapy-induced enrichment of putative lung cancer stem-like cells
Daniela P. Freitas et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
John C. Schell et al.
MOLECULAR CELL (2014)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale et al.
NATURE (2014)
Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin
Cristina Federici et al.
PLOS ONE (2014)
Glucose-Regulated Protein 78 ( Grp78) Confers Chemoresistance to Tumor Endothelial Cells under Acidic Stress
Fernanda Visioli et al.
PLOS ONE (2014)
Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
Maria Cristina Estan et al.
PLOS ONE (2014)
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma
Samuel A. Jensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
Mireille Khacho et al.
NATURE COMMUNICATIONS (2014)
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Young Seok Ju et al.
ELIFE (2014)
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
Courtney D. DiNardo et al.
BLOOD (2013)
PDK1 inhibition is a novel therapeutic target in multiple myeloma
S. Fujiwara et al.
BRITISH JOURNAL OF CANCER (2013)
Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib
W. Y. Sanchez et al.
BRITISH JOURNAL OF CANCER (2013)
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez et al.
CANCER CELL (2013)
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Rizwan Haq et al.
CANCER CELL (2013)
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
Luika A. Timmerman et al.
CANCER CELL (2013)
xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
Momoko Yoshikawa et al.
CANCER RESEARCH (2013)
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert et al.
CELL METABOLISM (2013)
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou et al.
CELL STEM CELL (2013)
Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells
I. S. Song et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Targeting lactate metabolism for cancer therapeutics
Joanne R. Doherty et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
Jennifer Pasquier et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2013)
Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
Giada Gelsomino et al.
MOLECULAR CANCER (2013)
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump
S. Fan et al.
ONCOGENE (2013)
BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery
J. Hagenbuchner et al.
ONCOGENE (2013)
Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma
Ping Yuan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
Gregory LaMonte et al.
CANCER & METABOLISM (2013)
Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
Pilar Caro et al.
CANCER CELL (2012)
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
Ralph J. DeBerardinis et al.
CELL (2012)
Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
Nitzan Gonen et al.
DRUG RESISTANCE UPDATES (2012)
Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance
Flora Guerra et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel
Isabel R. Schlaepfer et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells
Kakajan Komurov et al.
MOLECULAR SYSTEMS BIOLOGY (2012)
A possible role for oxidation stress in lymphoid leukaemias and therapeutic failure
Ana Bela Sarmento-Ribeiro et al.
LEUKEMIA RESEARCH (2012)
Passenger deletions generate therapeutic vulnerabilities in cancer
Florian L. Muller et al.
NATURE (2012)
Metabolism of [U-13C]glucose in human brain tumors in vivo
Elizabeth A. Maher et al.
NMR IN BIOMEDICINE (2012)
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
Robert J. Gillies et al.
NATURE REVIEWS CANCER (2012)
Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
Manuela Polimeni et al.
BIOCHEMICAL JOURNAL (2011)
Supplementation With Fish Oil Increases First-Line Chemotherapy Efficacy in Patients With Advanced Nonsmall Cell Lung Cancer
Rachel A. Murphy et al.
CANCER (2011)
Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
Yuhua Zhao et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Acidic stress promotes a glioma stem cell phenotype
A. B. Hjelmeland et al.
CELL DEATH AND DIFFERENTIATION (2011)
MicroRNA regulation of core apoptosis pathways in cancer
Raquel T. Lima et al.
EUROPEAN JOURNAL OF CANCER (2011)
AMP-activated protein kinase-an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
GENES & DEVELOPMENT (2011)
A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells
Joanna Kopecka et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
Rupal Ramakrishnan et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
Katrin Dietl et al.
JOURNAL OF IMMUNOLOGY (2010)
Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial
P. Bougnoux et al.
BRITISH JOURNAL OF CANCER (2009)
Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
Corina Kohler et al.
MOLECULAR CANCER (2009)
Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
Teresa W. M. Fan et al.
MOLECULAR CANCER (2009)
The xc- cystine/glutamate antiporter:: a mediator of pancreatic cancer growth with a role in drug resistance
M. Lo et al.
BRITISH JOURNAL OF CANCER (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38
Christoph Sauvant et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
Chun-Wun Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Hypoxia and metabolism - Opinion - A microenvironmental model of carcinogenesis
Robert A. Gatenby et al.
NATURE REVIEWS CANCER (2008)
Modification of the tumor microenvironment to enhance immunity
Yu-Pei Liao et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
E Gottfried et al.
BLOOD (2006)
Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
SJ Antonia et al.
CLINICAL CANCER RESEARCH (2006)
Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin
E Miraglia et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Clinical value of mitochondrial mutations in colorectal cancer
A Lièvre et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
RT Lima et al.
CANCER GENE THERAPY (2004)
Akt stimulates aerobic glycolysis in cancer cells
RL Elstrom et al.
CANCER RESEARCH (2004)
Analysis of drug transport kinetics in implications for drug action
A Garnier-Suillerot et al.
CURRENT MEDICINAL CHEMISTRY (2001)
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