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DRUG RESISTANCE UPDATES (2016)
Lysosomes as mediators of drug resistance in cancer
Benny Zhitomirsky et al.
DRUG RESISTANCE UPDATES (2016)
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Wen Li et al.
DRUG RESISTANCE UPDATES (2016)
HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer
Jian Yang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)
Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours
Katarzyna Stepien et al.
MEDICAL ONCOLOGY (2016)
Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
Catherine Marquer et al.
NATURE COMMUNICATIONS (2016)
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Hiroaki Semba et al.
NATURE COMMUNICATIONS (2016)
Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
Joanna Kopecka et al.
ONCOTARGET (2016)
Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions
Gaspard Cretenet et al.
SCIENTIFIC REPORTS (2016)
Overcoming Hypoxia-Mediated Tumor Progression:Combinatorial Approaches Targeting pH Regulation,Angiogenesis and Immune Dysfunction
Paul C. McDonald et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
Luana Schito et al.
TRENDS IN CANCER (2016)
Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1
Helena Doktorova et al.
BIOMEDICAL PAPERS-OLOMOUC (2015)
Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis
Justin V. Joseph et al.
CANCER LETTERS (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach
Sophie Taylor et al.
DRUG RESISTANCE UPDATES (2015)
The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade
Rishil J. Kathawala et al.
DRUG RESISTANCE UPDATES (2015)
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
Thibault Voron et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof
Tseng-Cheng Chen et al.
ORAL ONCOLOGY (2015)
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Huimin Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
Haiquan Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis et al.
NATURE COMMUNICATIONS (2015)
Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells
Joanna Kopecka et al.
ONCOTARGET (2015)
Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
Micol Rigoni et al.
ONCOTARGET (2015)
Tumor hypoxia drives immune suppression and immunotherapy resistance
Midan Ai et al.
Journal for ImmunoTherapy of Cancer (2015)
Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
Iris Chiara Salaroglio et al.
ONCOTARGET (2015)
Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
Benny Zhitomirsky et al.
ONCOTARGET (2015)
Palmitoylation of G alpha q Determines Its Association with the Thromboxane Receptor in Hypoxic Pulmonary Hypertension
Anuraq S. Sikarwar et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)
Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: A therapeutic implication
Dong Hoon Suh et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response
S. R. McKeown
BRITISH JOURNAL OF RADIOLOGY (2014)
The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Cyril Corbet et al.
CANCER RESEARCH (2014)
PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Muhammad Zaeem Noman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
Gregory T. Motz et al.
NATURE MEDICINE (2014)
The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition
Darren M. Hutt et al.
PLOS ONE (2014)
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
Erinn B. Rankin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
S. Raz et al.
CELL DEATH & DISEASE (2014)
Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists
Michail V. Sitkovsky et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
Olga Sedlakova et al.
FRONTIERS IN PHYSIOLOGY (2014)
The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition
Xiaofeng Jiang et al.
CLINICAL CANCER RESEARCH (2013)
Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC
Mirna Balsamo et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
Giada Gelsomino et al.
MOLECULAR CANCER (2013)
Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts
Anna Kiraly et al.
MARINE DRUGS (2013)
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
Andrew L. Doedens et al.
NATURE IMMUNOLOGY (2013)
Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia
Stephan A. Grupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
The VHL/HIF axis in clear cell renal carcinoma
Chuan Shen et al.
SEMINARS IN CANCER BIOLOGY (2013)
Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia
Sensen Lin et al.
CANCER SCIENCE (2012)
Combining angiogenesis inhibition and radiotherapy: A double-edged sword
Esther A. Kleibeuker et al.
DRUG RESISTANCE UPDATES (2012)
HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
Ainara Elorza et al.
MOLECULAR CELL (2012)
Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy
Yi Li et al.
LEUKEMIA & LYMPHOMA (2012)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid Malignancies
Glen J. Weiss et al.
CLINICAL CANCER RESEARCH (2011)
Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia
David L. Porter et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Interferon-γ and tumor necrosis factor-α induce an immunoinhibitory molecule, B7-H1, via nuclear factor-κB activation in blasts in myelodysplastic syndromes
Asaka Kondo et al.
BLOOD (2010)
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
James N. Kochenderfer et al.
BLOOD (2010)
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Z. Imtiyaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
Nadine Rohwer et al.
PLOS ONE (2010)
Tumor Angiogenesis: Insights and Innovations
Fernando Nussenbaum et al.
JOURNAL OF ONCOLOGY (2010)
Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
Holger K. Eltzschig et al.
BLOOD (2009)
Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance
Lili Liu et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1
Richard Sullivan et al.
MOLECULAR CANCER THERAPEUTICS (2009)
PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
C. A. Crane et al.
ONCOGENE (2009)
HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
Rose Du et al.
CANCER CELL (2008)
Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells
J. Hao et al.
CANCER GENE THERAPY (2008)
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts
Renato Wirthner et al.
CARCINOGENESIS (2008)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
How regulatory T cells work
Dario A. A. Vignali et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes
I. Stuart Wood et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells
Eran E. Bram et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
Andrew T. Parsa et al.
NATURE MEDICINE (2007)
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates
Eran Bram et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance
I Ifergan et al.
CANCER RESEARCH (2005)
ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates
A Shafran et al.
CANCER RESEARCH (2005)
Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells
RNT Coffey et al.
CANCER (2005)
HIF-1, O2, and the 3 PHDs:: How animal cells signal hypoxia to the nucleus
GL Semenza
CELL (2001)