期刊
DRUG METABOLISM REVIEWS
卷 54, 期 1, 页码 1-21出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03602532.2021.2001493
关键词
Gilbert's syndrome; Crigler-Najjar syndrome; neurological disease; hepatobiliary disease; tumorigenesis
资金
- National Sciences Foundation of China [81873055, 81503265]
- Jiangsu Science and Technology Development Project of Traditional Chinese Medicine [YB2020020]
- National TCM innovation backbone TCM innovation backbone talent training program [19ZYCXGG-2]
- Institute's independent research projects of Jiangsu Province Academy of Traditional Chinese Medicine [BM2018024-2019008]
UGT1A1 is the only enzyme capable of metabolizing detoxified bilirubin, and its inactivation can lead to diseases like GS and CN. UGT1A1 polymorphisms may be associated with neurological diseases, hepatobiliary diseases, cardiovascular diseases, etc., with ongoing research in this area.
UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and very low activity of UGT1A1 in the liver can be fatal or lead to lifelong Gilbert's syndrome (GS) and Crigler-Najjar syndrome (CN). To date, more than one hundred UGT1A1 polymorphisms have been discovered. Although most UGT1A1 polymorphisms are not fatal, which diseases might be associated with low activity UGT1A1 or UGT1A1 polymorphisms? This scientific topic has been studied for more than a hundred years, there are still many uncertainties. Herein, this article will summarize all the possibilities of UGT1A1 gene-related diseases, including GS and CN, neurological disease, hepatobiliary disease, metabolic difficulties, gallstone, cardiovascular disease, Crohn's disease (CD) obesity, diabetes, myelosuppression, leukemia, tumorigenesis, etc., and provide guidance for researchers to conduct in-depth study on UGT1A1 gene-related diseases. In addition, this article not only summarizes the prevention strategies of UGT1A1 gene-related diseases, but also puts forward some insights for sharing.
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