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Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice
Virginie F. Labrousse et al.
PLOS ONE (2009)
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
M. Britschgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Taking Complement to the Clinic - has the Time Finally Come?
P. J. Lachmann et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2009)
Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability
Matthew R. DiStasi et al.
TRENDS IN IMMUNOLOGY (2009)
Alzheimer's disease
Alistair Burns et al.
BMJ-BRITISH MEDICAL JOURNAL (2009)
Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice
Michelle C. Janelsins et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Active and passive immunotherapy for Neurodegenerative disorders
David L. Brody et al.
ANNUAL REVIEW OF NEUROSCIENCE (2008)
Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
ARCHIVES OF NEUROLOGY (2008)
Restraining tumor necrosis factor-alpha by thalidomide prevents the Amyloid beta-induced impairment of recognition memory in mice
Tursun Alkam et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Biology of immune responses to vaccines in elderly persons
Birgit Weinberger et al.
CLINICAL INFECTIOUS DISEASES (2008)
IFN-γ enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease
Rona Baron et al.
FASEB JOURNAL (2008)
Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease
Jun Zhou et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Mutant Amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine
Chuanhai Cao et al.
JOURNAL OF NEUROIMMUNOLOGY (2008)
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
Edward L. Tobinick et al.
JOURNAL OF NEUROINFLAMMATION (2008)
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
Melissa K. Mccoy et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
Marcel Maier et al.
JOURNAL OF NEUROSCIENCE (2008)
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
Tristan Bolmont et al.
JOURNAL OF NEUROSCIENCE (2008)
Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial
Clive Holmes et al.
LANCET (2008)
Repeated subcutaneous injections of IL12/23 P40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
Benjamin M. Segal et al.
LANCET NEUROLOGY (2008)
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Annett Halle et al.
NATURE IMMUNOLOGY (2008)
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
Terrence Town et al.
NATURE MEDICINE (2008)
TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
Filippo Caraci et al.
NEUROBIOLOGY OF DISEASE (2008)
Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology
Z. Arvanitakis et al.
NEUROLOGY (2008)
Protective effects of NSAIDs on the development of Alzheimer disease
Steven C. Vlad et al.
NEUROLOGY (2008)
The classical complement cascade mediates CNS synapse elimination
Beth Stevens et al.
CELL (2007)
Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Russell P. Rother et al.
NATURE BIOTECHNOLOGY (2007)
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
Ping He et al.
JOURNAL OF CELL BIOLOGY (2007)
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model
Oleg Butovsky et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Forecasting the global burden of Alzheimer's disease
Ron Brookmeyer et al.
ALZHEIMERS & DEMENTIA (2007)
Inflammatory markers and the risk of Alzheimer disease - The Framingham study
Z. S. Tan et al.
NEUROLOGY (2007)
Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease:: Relevance for the Behavioral and synaptic deficits induced by amyloid β protein
Rodrigo Medeiros et al.
JOURNAL OF NEUROSCIENCE (2007)
The role of dendritic cells in multiple sclerosis
Gregory F. Wu et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2007)
Interferon-γ and tumor necrosis factor-a regulate amyloid-α plaque deposition and β-secretase expression in Swedish mutant APP transgenic mice
Masaru Yamamoto et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Inflammatory processes in Alzheimer's disease
Michael T. Heneka et al.
JOURNAL OF NEUROIMMUNOLOGY (2007)
Increased T-cell reactivity and elevated levels of CD8(+) memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: Implications for immunotherapy
Katharina Schindowski et al.
NEUROMOLECULAR MEDICINE (2007)
Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
Hideyuki Takeuchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Synaptic scaling mediated by glial TNF-α
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NATURE (2006)
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
AR Simard et al.
NEURON (2006)
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
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NATURE NEUROSCIENCE (2006)
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
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JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2005)
Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients
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JOURNAL OF ALZHEIMERS DISEASE (2005)
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
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NEUROLOGY (2005)
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
Nikunj S. Patel et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
Michelle C. Janelsins et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Increased cerebrospinal fluid levels of transforming growth factor-β1 in Alzheimer's disease
H Zetterberg et al.
NEUROSCIENCE LETTERS (2004)
Cytokines in neuroinflammation and Alzheimer's disease
M Cacquevel et al.
CURRENT DRUG TARGETS (2004)
Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation -: Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-κB pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
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JOURNAL OF NEUROSCIENCE (2004)
Anti-interleukin-12 antibody for active Crohn's disease
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NEW ENGLAND JOURNAL OF MEDICINE (2004)
T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A direct interaction between transforming growth Factor (TGF)-βs and amyloid-β protein affects fibrillogenesis in a TGF-β receptor-independent manner
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid β-peptide presentation to Th1 cells
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JOURNAL OF IMMUNOLOGY (2003)
Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy
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CELL AND TISSUE RESEARCH (2003)
Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
A Monsonego et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
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NEUROLOGY (2003)
Tumor necrosis factor signaling
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CELL DEATH AND DIFFERENTIATION (2003)
Increased fibrillar beta-amyloid in response to human C1q injections into hippocampus and cortex of APP+PS1 transgenic mice
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NEUROCHEMICAL RESEARCH (2003)
CD45 isoform alteration in CD4+T cells as a potential diagnostic marker of Alzheimer's disease
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JOURNAL OF NEUROIMMUNOLOGY (2002)
Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
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JOURNAL OF NEUROSCIENCE RESEARCH (2002)
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Control of synaptic strength by glial TNFα
EC Beattie et al.
SCIENCE (2002)
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
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JOURNAL OF NEUROIMMUNOLOGY (2002)
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
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NATURE (2001)
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
HA Arnett et al.
NATURE NEUROSCIENCE (2001)
Decreased levels of intrathecal interleukin 1 receptor antagonist in Alzheimer's disease
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DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2001)
Signal transduction by tumor necrosis factor and its relatives
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TRENDS IN CELL BIOLOGY (2001)
Complement activation by neurofibrillary tangles in Alzheimer's disease
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NEUROSCIENCE LETTERS (2001)
The inhibitory effect of interleukin-1β on long-term potentiation is coupled with increased activity of stress-activated protein kinases
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JOURNAL OF NEUROSCIENCE (2000)
Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
JG Sheng et al.
EXPERIMENTAL NEUROLOGY (2000)
Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease
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IMMUNOBIOLOGY (2000)
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