期刊
DRUG DISCOVERY TODAY
卷 27, 期 7, 页码 1961-1973出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.02.010
关键词
Antibacterial; Repurposing; Auranofin; Gold complexes; Metal-based drug; Gram-positive bacteria; Gram-negative bacteria
资金
- National Natural Science Foundation of China [82173684, 81703337]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (Integration of Chinese and Western Medicine)
- Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine [2020YLXK010]
- General Project of Basic Science in Colleges and Universities of Jiangsu Province [21KJB350007]
- Jiangsu Provincial Health Commission [Z2021057]
- 'Innovative and Entrepreneurial Team' Program of Jiangsu Province (2020)
Multidrug resistance is a significant issue in antibiotic clinical application, leading researchers to explore the potential of auranofin and other gold complexes as antibacterial agents. These advances offer a new perspective on the treatment of bacterial infections.
Multidrug resistance (MDR) is a significant issue associated with the clinical application of antibiotics. It is also challenging to discover and develop new antibiotics with novel scaffolds. Therefore, the repurposing of existing drugs has become a promising strategy for antibiotic drug discovery. Auranofin, an approved gold metallic drug, has been used for the treatment of rheumatoid arthritis (RA) for many years. Recent research revealed that auranofin has strong antibacterial activity against multiple Gram-positive bacteria by inhibiting thioredoxin reductase (TrxR). These results inspired the development of gold complexes as antibacterial agents. Herein, we discuss recent advances in the development of auranofin and other gold complexes as antibacterial agents, providing a new viewpoint for the treatment of bacterial infection.
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