期刊
DRUG DELIVERY
卷 29, 期 1, 页码 161-173出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2021.2021322
关键词
Hollow mesoporous organosilica nanoparticles (HMONs); ovarian cancer; multimodal imaging; phototherapy; lysosomal disruption
资金
- National Science and Technology Support Program of China [2014BAI05B03]
- National Natural Science Foundation of China [82101701]
- Basic and Applied Basic Research Fund of Guangdong Province [2019A1515110337, 2021A1515010813]
- Guangdong Medical Science and Technology Research Fund Project [A2020077]
- Chinese Postdoctoral Science Foundation [2019M660207]
- Nanfang Hospital President Fund [2019C005]
A hollow mesoporous organosilica-based nanoplatform with mild-temperature photothermal therapeutic effect and multimodal imaging abilities was synthesized. It showed promising potential as an anticancer agent for ovarian cancer treatment.
A major impediment in the development of nanoplatform-based ovarian cancer therapy is endo/lysosome entrapment. To solve this dilemma, a hollow mesoporous organosilica-based nanoplatform (HMON@CuS/Gd2O3) with a mild-temperature photothermal therapeutic effect and multimodal imaging abilities was successfully synthesized. HMON@CuS/Gd2O3 exhibited an appropriate size distribution, L-glutathione (GSH)-responsive degradable properties, and high singlet oxygen generation characteristics. In this study, the nanoplatform specifically entered SKOV-3 cells and was entrapped in endo/lysosomes. With a mild near infrared (NIR) power density (.5 W/cm(2)), the HMON@CuS/Gd2O3 nanoplatform caused lysosome vacuolation, disrupted the lysosomal membrane integrity, and exerted antitumour effects in ovarian cancer. Additionally, our in vivo experiments indicated that HMON@CuS/Gd2O3 has enhanced T1 MR imaging, fluorescence (FL) imaging (wrapping fluorescent agent), and infrared thermal (IRT) imaging capacities. Using FL/MRI/IRT imaging, HMON@CuS/Gd2O3 selectively caused mild phototherapy in the cancer region, efficiently inhibiting the growth of ovarian cancer without systemic toxicity in vivo. Taken together, the results showed that these well-synthesized nanoplatforms are likely promising anticancer agents to treat ovarian cancer and show great potential for biomedical applications.
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