期刊
DNA AND CELL BIOLOGY
卷 40, 期 12, 页码 1503-1512出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2021.0674
关键词
KLF5; transcription factor; squamous cell carcinoma; cancer therapeutics
资金
- National Natural Science Foundation of China [81671497, 81971461]
KLF5 plays a critical role in squamous cell carcinomas and could be a novel diagnostic biomarker and therapeutic target for treatment.
Squamous cell carcinomas (SCCs) are the most common ectodermal cancers, and result in more than 300,000 deaths per year. The Kruppel-like family of transcription factors play a critical role in cancer pathogenesis. The Kruppel-like factor 5 gene (KLF5), which is a member of Kruppel-like family, has been reported to promote cancer cell proliferation and tumorigenesis. In this review, we discuss the roles of KLF5 in different SCCs and the mechanisms by which KLF5 transcriptionally regulates its target gene expression in the pathogenesis and progression of SCCs. Due to its significant functions in cell proliferation and differentiation, KLF5 could be a novel diagnostic biomarker and therapeutic target for the treatment of SCCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据