期刊
DIGESTIVE DISEASES AND SCIENCES
卷 67, 期 9, 页码 4492-4499出版社
SPRINGER
DOI: 10.1007/s10620-021-07318-2
关键词
Gastroparesis; G-POEM; POP; ICC; Outcome; Pathophysiology; Submucosal endoscopy
This study presents a new technique for obtaining gastric muscle samples and quantifying the number of Interstitial Cells of Cajal (ICC) in patients with gastroparesis. The results suggest that the number of ICC may be related to the response to treatment. However, further studies with a larger number of patients are needed to confirm these findings.
Background The role of Interstitial Cells of Cajal (ICC) in the pathogenesis of gastroparesis has been suggested by previous studies due to their involvement in the transmission of neuronal signaling to the smooth muscles of the GI tract. However, studies have been limited by the inability to obtain a gastric muscle sample, since routine endoscopy can only biopsy the mucosa. We present a new technique of muscle biopsy during per-oral endoscopic pyloromyotomy (GPOEM), a novel endoscopic procedure for treatment of gastroparesis. Patients and Methods All enrolled patients had diagnosed gastroparesis and had biopsies of the muscular layer at the antrum/pylorus during POEM. All GPOEM procedures took place from August 2019 to December 2019. Various demographic, disease-related, and procedure-related data were collected from chart review. ICC in the biopsy specimen was examined and quantitated. Results Through this method, we readily expose the gastric muscle of 21 patients through dissection of a gastric submucosal tunnel during GPOEM and provide reliable muscle sample for ICC quantification. Average number of ICC were higher in clinical responders (88 ICC +/- 63 vs. 39 ICC +/- 24, p = 0.02), defined as those who experienced significant improvement in nausea and vomiting symptoms after GPOEM. Conclusions This study provides a reliable novel biopsy method for safely biopsy gastric muscle for quantitating the number of gastric ICC in patients with gastroparesis. The number of ICC may be related to the outcome of GPOEM therapy. However, further studies with larger number of patients are needed to confirm the results.
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