期刊
DIGESTIVE DISEASES AND SCIENCES
卷 67, 期 11, 页码 5195-5205出版社
SPRINGER
DOI: 10.1007/s10620-022-07388-w
关键词
Incidence; Inflammatory bowel diseases; Japan; Risk factors; Venous thromboembolism
资金
- Pfizer Japan Inc, Tokyo, Japan [163:461-464]
This study provides insight into the incidence and risk factors for VTE in patients with IBD from Japan.
Background Inflammatory bowel disease (IBD), which encompasses both ulcerative colitis (UC) and Crohn's disease (CD), is a risk factor for venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Aim To investigate the incidence of, and risk factors for, VTE in patients with IBD in Japan. Methods This was a retrospective, non-interventional study in patients with IBD from the Japan Medical Data Center claims database. Incidence rates (IRs; unique patients with events per 100 patient-years) were calculated for VTE, DVT, and PE among the IBD, UC, and CD cohorts. Odds ratios of potential risk factors were calculated by univariate and multivariate analyses in a nested case-control design. Results Overall, 16 273 patients with IBD were included: 13 585 with UC and 3443 with CD. VTE events occurred in 1.3%, 1.2%, and 1.9% of patients with IBD, UC, and CD, respectively. In patients with IBD, UC, and CD, IRs of VTE were 0.45, 0.40, and 0.64, respectively, IRs of DVT were 0.42, 0.38, and 0.61, respectively, and IRs of PE were 0.07, 0.07, and 0.11, respectively. In patients with IBD, treatment history (immunomodulators), cardiovascular risk (hypertension, high-density lipoprotein or diabetes mellitus, and history of coronary artery disease or heart failure), malignancy, and undergoing major surgery were identified as potential risk factors for VTE in the multivariate analysis, with similar risk factors reported for patients with UC and CD. Conclusions This large study provides insight into the incidence and risk factors for VTE in patients with IBD from Japan.
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