期刊
DIFFERENTIATION
卷 122, 期 -, 页码 1-6出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2021.11.001
关键词
Extracellular matrix; Mechanotransduction; Reprogramming; YAP; TAZ; ENH
资金
- Affiliated Hospital of Southwest Medical University
Stem cells are crucial in regenerative medicine and cell therapy, and mechanical signals in the cellular microenvironment play an important role in inducing reprogramming of somatic cells into stem cells. These signals may activate physical and chemical pathways, with the ENH protein likely playing a key role in connecting and regulating these pathways. This illustrates a new strategy for inducing and regulating reprogramming in vitro through physical processes related to local mechanical forces.
Stem cells are crucial in the fields of regenerative medicine and cell therapy. Mechanical signals from the cellular microenvironment play an important role in inducing the reprogramming of somatic cells into stem cells in vitro, but the mechanisms of this process have yet to be fully explored. Mechanical signals may activate a physical pathway involving the focal adhesions-cytoskeleton-LINC complex axis, and a chemical pathway involving YAP/ TAZ. ENH protein likely plays an important role in connecting and regulating these two pathways. Such mechanisms illustrate one way in which mechanical signals from the cellular microenvironment can induce reprogramming of somatic cells to stem cells, and lays the foundation for a new strategy for inducing and regulating such reprogramming in vitro by means of physical processes related to local mechanical forces.
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