The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study

Background: Although there is abundant evidence for an association between dietary pattern, weight, and other related factors, such as homeostatic model assessment for insulin resistance (HOMA-IR) and inflammatory markers; there is limited information pertaining to levels of plasminogen activator inhibitor-1 (PAI-1) and Monocyte Chemoattractant Protein-1 (MCP-1). Therefore, this study sought to examine the association between adherence to the dietary approaches to stop hypertension (DASH) diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR. Methods: This cross-sectional study was performed on 305 obese and overweight women. The typical food intake of individuals was assessed using the 147 items semi quantitative food frequency questionnaire (FFQ). Body components were measured for all participants. Insulin resistance was estimated by homeostasis model assessment (HOMA), and biochemical parameters were examined. Results: No significant relationship was observed between the DASH diet and MCP-1(P trend = 0.70), PAI-1 (P-trend = 0.92), or HOMA-IR (P-trend = 0.08) in the crude model. How ever, there was a significant inverse relationship between the DASH diet and HOMA-IR (P-trend = 0.03) after adjusting for age, BMI, and physical activity. Conclusion: This study showed that higher adherence to DASH pattern is inversely corre-lated with HOMA-IR in overweight and obese women. (c) 2021 Published by Elsevier B.V.

Automated summary

This study examined the association between adherence to the DASH diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR in overweight and obese women. The results showed a significant inverse relationship between adherence to the DASH pattern and HOMA-IR after adjusting for age, BMI, and physical activity.