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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
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JCI INSIGHT (2020)
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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
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Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors
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DIABETOLOGIA (2017)
The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice
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DIABETES CARE (2016)
N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor
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BRITISH JOURNAL OF PHARMACOLOGY (2016)
Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the G alpha(q) pathway
Aiysha Thompson et al.
BIOCHEMICAL PHARMACOLOGY (2015)
Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect
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JOURNAL OF CLINICAL INVESTIGATION (2014)
Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation
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JOURNAL OF IMMUNOLOGY (2014)
A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity
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GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis
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PLOS ONE (2012)
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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2011)
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Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
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Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes:: a parallel-group study
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LANCET (2002)
Reduced postprandial concentrations of intact biologically active gluccagon-like peptide 1 in type 2 diabetic patients
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