The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here, we integrate high-confidence, systematically generated human, mouse, and fly data from studies on LDs in the framework of an online platform named the Lipid Droplet Knowledge Portal(https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.

Automated summary

Lipid droplets (LDs) are organelles responsible for cellular lipid storage and play fundamental roles in energy metabolism and cell membrane homeostasis. Due to their relevance in lipid storage diseases, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis, there has been a growing need for a resource that combines systematically generated datasets on LD biology. The Lipid Droplet Knowledge Portal is an online platform that integrates high-confidence human, mouse, and fly data, providing a comprehensive resource for LD biology, including transcriptional profiles, proteomics, genome-wide screen phenotypes, and links to human genetics.