4.1 Article

Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation

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Summary: Recent studies have identified a population of bipotent neuromesodermal progenitors in the posterior region of the embryo, which possess the ability to generate spinal cord and paraxial mesoderm cells with a conserved regulatory network. By maintaining this flexible pool of multi-germ layer competent progenitors, the contribution to the elongating body axis can vary depending on relative growth rates in different regions, suggesting a potential role in driving alterations in the timing of embryo growth during evolution.

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