期刊
DEVELOPMENT
卷 149, 期 3, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.200210
关键词
Adult neurogenesis; Maturation; Olfaction; Olfactory bulb development
资金
- Horizon 2020 European Research Council Consolidator Grant (FUNCOPLAN) [725729]
- Biotechnology and Biological Sciences Research Council [BB/V000195/1]
- King's College London
- European Research Council (ERC) [725729] Funding Source: European Research Council (ERC)
This review summarizes the development of the mammalian olfactory bulb, including prenatal, postnatal, and adult stages, focusing on the maturation, morphology, functions, and interactions of its diverse glutamatergic and GABAergic cell types. The review highlights the significant advances made in understanding olfactory bulb development in recent years, as well as the remaining gaps in knowledge that require urgent attention.
The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. The olfactory bulb forms early during development and is functional from birth. However, the olfactory system continues to mature and change throughout life as a target of constitutive adult neurogenesis. Our Review synthesises current knowledge of prenatal, postnatal and adult olfactory bulb development, focusing on the maturation, morphology, functions and interactions of its diverse constituent glutamatergic and GABAergic cell types. We highlight not only the great advances in the understanding of olfactory bulb development made in recent years, but also the gaps in our present knowledge that most urgently require addressing.
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