4.7 Article

Microfluidic systems for modeling human development

期刊

DEVELOPMENT
卷 149, 期 3, 页码 -

出版社

COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.199463

关键词

Biophysics; Microfluidics; Microphysiological systems; Organs-on-chips; Tissue engineering; In vitro models

资金

  1. Whitehead Foundation
  2. National Institutes of Health [T32GM800555]
  3. International Foundation for Ethical Research

向作者/读者索取更多资源

Microfluidic systems and organs-on-chips offer new ways to understand how microenvironmental factors contribute to cell fate decisions and physiological processes. They enable us to study how extracellular signals affect cell differentiation, how cells interact with each other, and how different tissues and organs are formed for specialized functions.
The proper development and patterning of organs rely on concerted signaling events emanating from intracellular and extracellular molecular and biophysical cues. The ability to model and understand how these microenvironmental factors contribute to cell fate decisions and physiological processes is crucial for uncovering the biology and mechanisms of life. Recent advances in microfluidic systems have provided novel tools and strategies for studying aspects of human tissue and organ development in ways that have previously been challenging to explore ex vivo. Here, we discuss how microfluidic systems and organs-on-chips provide new ways to understand how extracellular signals affect cell differentiation, how cells interact with each other, and how different tissues and organs are formed for specialized functions. We also highlight key advancements in the field that are contributing to a broad understanding of human embryogenesis, organogenesis and physiology. We conclude by summarizing the key advantages of using dynamic microfluidic or microphysiological platforms to study intricate developmental processes that cannot be accurately modeled by using traditional tissue culture vessels. We also suggest some exciting prospects and potential future applications of these emerging technologies.

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