4.5 Article

Proactive therapy: New perspectives for long-term topical treatment of psoriasis

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Summary: This article reviews the unmet needs in long-term management of psoriasis, suggesting that topical therapies could be the best treatment option in certain phases of the chronic disease. It calls for clinical alignment on terminology, recommending 'long-term management' as the most appropriate term, and provides recommendations for the implementation of topicals as part of long-term management strategies.

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Clinical, patient and estimated cost benefits of proactive management versus reactive management with calcipotriol/betamethasone dipropionate foam for the treatment of plaque psoriasis in Finland

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Summary: The study found that proactive management with Cal/BD foam showed consistent clinical benefits compared to reactive management on all response criteria, and resulted in significantly lower cost-per-responder for mPASI 75, mPASI <= 2, and DLQI <= 1 criteria. The analysis demonstrated the cost-effectiveness and clinical benefits of proactive management of plaque psoriasis with Cal/BD foam in the Finnish healthcare setting.

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Quality of life and patient-perceived symptoms in patients with psoriasis undergoing proactive or reactive management with the fixed-dose combination Cal/BD foam: A post-hoc analysis of PSO-LONG

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Summary: This study analyzed the impact of long-term use of fixed-dose combination calcipotriene and betamethasone dipropionate foam on health-related quality of life and symptom severity in patients with psoriasis. Results showed that patients in the proactive management arm had significantly better DLQI and PSI scores compared to the reactive management arm. In addition, in terms of PROs, patients with baseline flare had worse outcomes than those with relapse or in remission.

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Calcipotriol/Betamethasone Dipropionate Foam Inhibits Th17 Cytokine Secretion and Improves Epidermal Barrier Markers in a Human Th17 Skin Inflammation Model

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Summary: In this study, the effects of a fixed-dose combination of Cal/BD foam and CP cream on Th17 cytokine secretion and epidermal differentiation were investigated. Cal/BD foam significantly inhibited Th17 cytokine secretion and improved the expression of epidermal differentiation markers, while CP cream reduced Th17 cytokine levels to a lesser extent and did not improve epidermal differentiation markers.

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Early efficacy and safety data with fixed-dose combination calcipotriol/betamethasone dipropionate foam attributed to mechanism of absorption and steroid potency

Y. Tada et al.

Summary: This article discusses the potency and absorption of fixed-dose combination Cal/BD foam, as well as the positive early efficacy and safety data associated with its utilization in the treatment of psoriasis vulgaris. Early data indicate that Cal/BD foam forms a supersaturated solution on the skin, increasing the penetration and bioavailability of Cal and BD, resulting in improved efficacy outcomes without negatively affecting safety outcomes.

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