4.7 Article

Luminescent iridium(III) dipyrrinato complexes: synthesis, X-ray structures, and DFT and photocytotoxicity studies of glycosylated derivatives

期刊

DALTON TRANSACTIONS
卷 51, 期 10, 页码 3849-3863

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt04218a

关键词

-

资金

  1. IIT Gandhinagar
  2. DST [IF190158]

向作者/读者索取更多资源

Luminescent Ir(III) dipyrrinato complexes with various aromatic chromophores were synthesized, showing strong emission in the red to NIR region and large Stokes shifts. Glycosylated Ir(III) complexes exhibited strong photoluminescence in vitro and significant photocytotoxicity in skin keratinocyte and lung adenocarcinoma cells.
A series of luminescent Ir(III) dipyrrinato complexes were synthesized having various aromatic chromophores at the C-5 position of dipyrrin ligands. The presence of different chromophores on the Ir(III) dipyrrinato complexes altered their optical properties and produced strong emission in the red to NIR region (680-900 nm) with huge Stokes shifts (5910-7045 cm(-1)). TD-DFT studies indicated significant charge distribution between dipyrrin ligands and Ir-cyclometalated units in all the molecules. X-ray crystal structures revealed an octahedral geometry of the Ir(III) center in the complex. The in vitro studies of the glycosylated Ir(III) complexes revealed strong photoluminescence with maximum Stokes shifts, and they showed significant photocytotoxicity in skin keratinocyte (HaCaT) and lung adenocarcinoma (A549) cells. The singlet oxygen generation quantum yields of glycosylated Ir(III) complexes were in the range of 70-78% in water. The estimated IC50 values were between 17 and 25 mu M after light exposure, and confocal microscopy revealed significant localization of the glycosylated Ir(III) complexes in the endoplasmic reticulum (ER) of cancer cells. The neutral Ir(iii) dipyrrinato complexes are promising tracking agents for cellular imaging in the biological window and for photodynamic therapy (PDT) applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据