期刊
CURRENT VASCULAR PHARMACOLOGY
卷 20, 期 1, 页码 52-61出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570161119666211006114258
关键词
Aspirin; blood pressure; cardiovascular diseases; hypertension; preeclampsia; pregnancy complications; pulse wave analysis; vascular stiffness
Arterial stiffness (AS) is a predictor of cardiovascular morbidity and mortality, particularly in pregnant women with preeclampsia (PE). Current clinical practice only uses low-dose aspirin for PE prevention, which does not protect against term PE. AS assessment may serve as a promising predictive marker for PE development.
Arterial Stiffness (AS) describes the rigidity of the arterial walls. Epidemiological studies have shown that increased AS is an independent predictive marker of Cardiovascular (CV) morbidity and mortality in both pregnant and non-pregnant women. Preeclampsia (PE), a form of pregnancy-induced hypertension, affects approximately 5% of pregnancies worldwide. Preeclamptic women have a higher risk of CV Disease (CVD), mainly because PE damages the heart's ability to relax between contractions. Different pharmacological approaches for the prevention of PE have been tested in clinical trials (e.g., aspirin, enoxaparin, metformin, pravastatin, and sildenafil citrate). In current clinical practice, only low-dose aspirin is used for PE pharmacoprevention. However, low-dose aspirin does not prevent term PE, which is the most common form of PE. Compromised vascular integrity precedes the onset of PE and therefore, AS assessment may constitute a promising predictive marker of PE. Several non-invasive techniques have been developed to assess AS. Compared with normotensive pregnancies, both Carotid-Femoral Pulse Wave Velocity (cfPWV) and Augmentation Index (AIx) are increased in PE. In view of simplicity, reliability, and reproducibility, there is an interest in oscillometric AS measurements in pregnancies complicated by PE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据