Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine

Cardiovascular disease is a major disease affecting human health, and its pathogenesis is caused by many factors. Through the use of omics technology, precision medicine is playing an increasingly important role in the prevention and treatment of cardiovascular diseases. Dialectical treatment with traditional Chinese medicine (TCM)will result in personalized treatment, which is consistent with precision medicine to a certain extent. However, due to the multitarget, multipath, and multistep characteristics of TCM, its mechanism of action is not easy to elucidate. Network pharmacology can be used to predict the mechanism, toxicity and metabolic characteristics of TCM. This review summarizes commonly used bioinformatics resources for cardiovascular diseases and TCM, as well as the opportunities and challenges of TCM in cardiovascular precision medicine, with special emphasis on network pharmacology methods.

Automated summary

Cardiovascular disease is a major health concern with multifactorial pathogenesis. Precision medicine and traditional Chinese medicine offer personalized treatments, but the complex multi-target nature of TCM makes its mechanism challenging to elucidate. Network pharmacology proves useful in predicting the mechanism of action.