期刊
CURRENT PHARMACEUTICAL DESIGN
卷 28, 期 1, 页码 36-45出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612827666210927164935
关键词
Galectin-1; galectin-3; autoimmune diseases; systemic lupus erythematosus; rheumatoid arthritis; systemic sclerosis; type 1 dia-betes mellitus
资金
- National Natural Science Foundation of China [81872687]
Galectins are a protein family that plays important roles in physiological and pathological processes, including inflammation and autoimmune diseases. Recent studies have shown that galectins are involved in the occurrence and development of autoimmune diseases, providing potential therapeutic targets.
Galectins are a highly conserved protein family that binds to 13-galactosides. Different members of this family play a variety of biological functions in physiological and pathological processes such as angiogenesis, regulation of immune cell activity, and cell adhesion. Galectins are widely distributed and play a vital role both inside and outside cells. They can regulate homeostasis and immune function in vivo through mechanisms such as apoptosis. Recent studies have indicated that galectins exhibit pleiotropic roles in inflammation. Furthermore, emerging studies have found that galectins are involved in the occurrence and development of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes (T1D), and systemic sclerosis (SSc) by regulating cell adhesion, apoptosis, and other mechanisms. This review will briefly discuss the biological characteristics of the two most widely expressed and extensively explored members of the galectin family, galectin-1 and galectin-3, as well as their pathogenetic and therapeutic roles in autoimmune diseases. This information may provide a novel and promising therapeutic target for autoimmune diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据