4.5 Review

The Expedition of Azido-reductive Cyclization Approaches Towards Various Heterocycles

期刊

CURRENT ORGANIC CHEMISTRY
卷 26, 期 4, 页码 382-398

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272826666220218095203

关键词

Aza-sugars; azido-reductive cyclization; benzodiazepines; lactams; pyrroles; quinazolinones

资金

  1. Department of Pharmaceuticals (DoP), Ministry of Chemicals & Fertilizers, Govt. of India

向作者/读者索取更多资源

This review focuses on the azido-reductive cyclization of organic azides and its significant insights. The review elaborates the extensive literature for synthesizing various heterocycles using chemoselective and straightforward protocols for azido-reduction with concomitant intramolecular cyclization. The azido-reductive cyclization strategy has been successfully applied in the synthesis of essential heterocycles and various iminosugars, drugs/APIs, and natural products embedding such heterocycles.
Organic azides are placed in the interphase between chemistry, biology, medicine, and materials science. Their uses in peptide chemistry, combinatorial chemistry, and the synthesis of heterocycles are extensively explored. In this review, the focus is placed on the azido-reductive cyclization of azides and detailed its significant insights. The wide-ranging literature for synthesizing various heterocycles, employing chemoselective and straightforward protocols for azido-reduction with concomitant intramolecular cyclization, has been elaborated. In due course, the azido-reductive cyclization strategy witnessed the synthesis of essential heterocycles, such as benzodiazepine, quinazolinone, piperidine, pyrrole and their derivatives. In addition, the review includes application of azido-reductive cyclization strategies towards the synthesis of various iminosugars, drugs/APIs, and natural products embedding such heterocycles.

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