Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold

Pyrido[2,3-d]pyrimidine is an N -fused heterocyclic compound formed by the ortho fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic, antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic, etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual field of research. Moreover, the construction of elaborate biologically relevant moieties via a multicomponent approach has become a promising area of research, owing to the burgeoning 'green chemistry drive'. Advances in the exploitation of proficient synthetic routes involving a multicomponent approach for the assembly of this scaffold are reported in this review.

Automated summary

Pyrido[2,3-d]pyrimidines play a significant role in medicinal chemistry due to their diverse biological activities, and their synthesis is an ongoing area of research. Constructing biologically relevant moieties through a multicomponent approach is a promising research direction, driven by the increasing emphasis on 'green chemistry'.